Abstract
Candidiasis, an opportunistic infectious condition caused by the genus Candida, is the most common oral fungal infection in humans. The diagnosis of oral candidiasis can often be made based on recognition of its clinical pattern, but at times there is difficulty in making a clinical diagnosis because of its various manifestations. Several antifungal medications have been developed for managing fungal infections. Despite the availability of several effective antimycotics for the treatment of oral candidiasis, failure of therapy is not uncommon due to the unique environment of the oral cavity, where the flushing effect of saliva and the cleaning action of the oral musculature tend to reduce the drug concentration to sub-therapeutic levels. In this case report, we present two patients diagnosed with chronic hyperplastic candidiasis and median rhomboid glossitis, which are known as rare forms of candidiasis. In both cases, there was a significant reduction of clinical signs and symptoms when fluconazole was prescribed after the failure of initial nystatin therapy.
구강 캔디다증은 주요 기회감염 균주인 Candida 속(屬) 진균류에 의한 감염성 질환으로 구강점막에 발생하는 진균 감염 중 가장 흔하지만, 만성증식성(chronic hyperplastic type)이나 정중능형설염(median rhomboid glossitis)과 같이 드문 형태의 경우 오진의 가능성이 있고 효과적인 치료법의 결정도 어려운 경우가 있다. 본 증례에서는 만성증식성 구강 캔디다증 및 정중능형설염으로 진단된 환자에서 nystatin 처방에 효과적으로 반응하지 않아 fluconazole을 투여하여 증상의 경감과 치유를 보인 예를 보고하고자 한다.