Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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한국 소아에서 7가 폐렴사슬알균 단백결합 백신의 추가접종 면역원성에 관한 연구

Immunogenicity of 7-valent pneumococcal conjugate vaccine related to booster immunization in Korean children

  • 박소은 (포천중문의과대학 소아과학교실) ;
  • 이현주 (이화여자대학교 의과대학 소아과학교실) ;
  • 임수영 (이화여자대학교 의과대학 의과학연구소 백신효능 연구센터) ;
  • 김경효 (이화여자대학교 의과대학 소아과학교실)
  • Park, So Eun (Department of Pediatrics, College of Medicine, Pochon CHA University) ;
  • Lee, Hyunju (Department of Pediatrics, School of Medicine, Ewha Womans University) ;
  • Lim, Soo Young (Center for Vaccine Evaluation and Study, Ewha Medical Research Institute) ;
  • Kim, Kyung Hyo (Department of Pediatrics, School of Medicine, Ewha Womans University)
  • 투고 : 2008.04.21
  • 심사 : 2008.05.21
  • 발행 : 2008.06.15
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초록

목 적 : 본 연구는 우리나라 소아에서 면역원성에 근거한 추가접종의 필요성 여부를 확인하고자 하였다. 방 법 : 2006년 9월부터 2006년 12월까지 강남 차병원에 내원하여 검사를 위해 혈액 채취의 기회가 있었던 12-23개월 사이의 소아 39명을 대상으로 하였다. 7가 폐렴사슬알균 단백결합 백신의 접종력에 따라 기초접종 군과 추가접종 군으로 나누었다. 백신에 포함된 혈청형(4, 6B, 9V, 14, 18C, 19F, 23F)에 대하여 각각의 폐렴사슬알균 피막다당질 항체를 3세대 효소면역측정법으로 측정하였다. 결 과 : 각 혈청형에 대한 폐렴사슬알균 피막다당질 항체의 기하평균은 기초접종만 완료한 군보다 추가접종을 완료한 군에서 높았다(P<0.05). 폐렴사슬알균 피막다당질 항체가가 $0.35{\mu}g/mL$ 이상인 비율은 기초접종과 추가접종 군 모두에서 90.5-100%였다. 폐렴사슬알균 피막다당질 항체가가 $1.0{\mu}g/mL$ 이상인 비율은 추가접종 군에서 94.4-100%로 혈청형 6B와 14를 제외하고는 기초접종 군 보다 높았다(P<0.05). 폐렴사슬알균 피막다당질 항체가가 $5.0{\mu}g/mL$ 이상인 비율은 추가접종 군에서 50.0-94.4%로 모든 혈청형에서 기초접종 군 보다 높았다(P<0.05). 결 론 : 우리나라 소아에서 추가접종 후의 면역원성은 매우 좋았고 기초접종 이후에도 비교적 좋음을 알 수 있었다. 우리나라에 폐렴사슬알균 단백결합 백신의 도입과 접종 횟수를 결정하기 위해서는 전향적인 면역원성 연구가 지속되어야 할 것이라 생각된다.

Purpose : The purpose of this study was to evaluate the immunogenicity of the booster immunization with pneumococcal conjugate vaccine in Korean children. Methods : Thirty-nine children aged 12-23 months who visited Kangnam CHA Hospital between September 2006 and December 2006 were enrolled. The children were divided into primary and booster groups depending on their vaccination status for the 7-valent pneumococcal conjugate vaccine. The anti-pneumococcal antibody levels of each serotype included in the vaccine (4, 6B, 9V, 14, 18C, 19F, 23F) were determined by third-generation ELISA. Results : The geometric mean titer (GMT) of antibodies to each pneumococcal serotype in the booster group was higher than in the primary group (P<.05). The percentage of subjects with pneumococcal antibodies ${\geq}0.35{\mu}g/mL$ was 90.5-100% for all serotypes in both the primary and booster groups. The percentage of subjects with pneumococcal antibodies ${\geq}1.0g/mL$ in the booster group was 94.4-100%, which was higher than the primary group except for serotypes 6B and 14 (P<.05). The percentage of subjects with pneumococcal antibodies ${\geq}5.0{\mu}g/mL$ in the booster group was 50.0-94.4% which was higher than the primary group for all serotypes (P<0.05). Conclusion : The immunogenicity of a booster dose of the pneumococcal conjugate vaccine in Korean children was high and the immunogenicity of a primary series was also relatively high. To determine the feasibility of the introduction of the pneumococcal conjugate vaccine and the appropriate schedule for Korean children, further prospective investigation of the immunogenicity of the booster immunization is needed.

키워드

참고문헌

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피인용 문헌

  1. The 7-valent pneumococcal conjugate vaccine elicits cross-functional opsonophagocytic killing responses to Streptococcus pneumoniae serotype 6D in children vol.13, pp.None, 2008, https://doi.org/10.1186/1471-2334-13-474