Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
권호 표지

A Comparative Study of the Prolonged Effect with Neurectomy & Botox Injection Method on the Gastrocnemius Muscle Hypertrophy

비복근비대의 치료 방법인 신경절단술과 보톡스 주사법의 지속효과 비교에 대한 실험적 연구

  • Kwan, Sung Tak (Department of Plastic and Reconstructive Surgery, Seoul National University, College of Medicine) ;
  • Joo, Chun Seung (Ever Plastic Surgery Clinic)
  • 권성택 (서울대학교 의과대학 성형외과학교실) ;
  • 주춘승 (에버성형외과)
  • Received : 2007.08.09
  • Published : 2008.01.10
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Abstract

Purpose: There was no controlled study on botox injection and neurectomy for treatments of muscle hypertrophy. Although many studies have shown the clinical effects of each treatment, it was not able to evaluate and compare the effects of each treatment because there was no comparison of the two treatments under the same experimental condition. Hence, the aim of this study is to com Methods: The study was carried out on 21 rabbits. 9 rabbits received botox injection(botox injection group), and neurectomy was performed to another 9 rabbits (neurectomy group). 3 rabbits did not receive any treatment(control group). To compare and analyze the effects of muscular atrophy, muscle was stained with NADH-TR, and the changes in size of the muscle fiber were examined. And the electromyography was examined. In each group, muscle fiber was stained and electromyography was performed 2, 3, and 6 months after injection or operation. Results: In histological test and electromyography, in the neurectomy group, the size of muscular fiber and amplitude of electromyography decreased until 2 months after neurectomy. And decreased results were maintained with the passage of time. It showed irreversible aspect. On the other hand, in the botox injection group, the decrease in the size of muscular fiber and amplitude of electromyography was observed until 2 months after injection. In 3 months after the injection, it was slowly getting back to original size and had almost recovered by 6 months after the injection. It showed reversible aspect. Conclusion: This study shows researches about clinical effect of botox injection and neurectomy coincide with the results of experiment under the same experimental condition.

Keywords

Acknowledgement

Supported by : 서울대학교 병원

References

  1. Kim IG, Hwang SH, Lew JM, Lee HY: Endoscope- assisted calf reduction in orientals. Plast Reconstr Surg 106: 713, 2000 https://doi.org/10.1097/00006534-200009030-00032
  2. Lee HJ, Lee DW, Park YH, Cha MK, Kim HS, Ha SJ: Botulinum toxin A for aesthetic contouring of enlarged medial gastrocnemius muscle. Dermatol Surg 30: 867, 2004 https://doi.org/10.1111/j.1524-4725.2004.30255.x
  3. Moore AP, Wood GD: The medical management of masseteric hypertrophy with botulinum toxin type A. Br J Oral Maxillofac Surg 32: 29, 1994 https://doi.org/10.1016/0266-4356(94)90169-4
  4. Park MY, Ahn KY Jung DS: Botulinum toxin type A treatment for contouring of the lower face. Dermatol Surg 29: 477, 2003 https://doi.org/10.1046/j.1524-4725.2003.29116.x
  5. Kim JH, Shin JH, Kim ST, KIM CY: Effects of two different units of botulinum toxin type A evaluated by computed tomography and electromyographic measurements of human masseter muscle. Plast Reconstr Surg 119: 711, 2007 https://doi.org/10.1097/01.prs.0000239453.67423.99