Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Autoimmune hepatitis and thyroiditis associated with antituberculous medications : A case report

항결핵약으로 유발되고 갑상선염이 동반된 자가면역간염 1례

  • Yu, Seong Keun (Department of Pediatrics, Inje University Ilsan Paik Hospital) ;
  • Kim, Sara (Department of Pediatrics, Inje University Ilsan Paik Hospital) ;
  • Moon, Jin Soo (Department of Pediatrics, Inje University Ilsan Paik Hospital) ;
  • Kim, Han Seong (Department of Pathology, Inje University Ilsan Paik Hospital)
  • 유성근 (인제대학교 의과대학 소아과학교실) ;
  • 김사라 (인제대학교 의과대학 소아과학교실) ;
  • 문진수 (인제대학교 의과대학 소아과학교실) ;
  • 김한성 (인제대학교 의과대학 병리과교실)
  • Received : 2007.11.02
  • Accepted : 2008.01.22
  • Published : 2008.05.15
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Abstract

Drug-induced toxic hepatitis is a relatively common hepatic disease in children, and it is usually self-limiting upon cessation of the offending drugs. Antituberculous drugs are well known for inducing hepatitis. Some cases of drug-induced hepatitis with autoimmune features have been reported; in these cases, the offending drugs were usually methyldopa, nitrofurantoin, minocycline, and interferon. The authors report the first case in Korea of drug-induced autoimmune hepatitis associated with thyroiditis and multiple autoantibodies that was induced by the antituberculous drugs isoniazid and rifampin.

소아에서 약물 유발성 독성 간염은 비교적 흔하며 대부분 약을 끊으면 호전된다. 특히 항결핵약은 주요 유발 약물이다. 약물 유발성 독성 간염은 자가면역질환을 동반할 수 있으며, 이러한 원인으로 보고된 약제로는 주로 methyldopa, nitrofurantoin, minocycline, interferon 등이고, 항결핵약 보고는 드물다. 저자들은 갑상선염이 동반되고 항결핵약 isoniazid와 rifampin으로 유발된 약물 유발성 자가면역간염을 경험하였기에 국내에서 처음으로 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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