Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Coronary artery diameter of normal children aged 3 months to 6 years

생후 3개월에서 7세 미만 정상 소아에서의 관상동맥 직경

  • Yu, Jeong Jin (Department of Pediatrics, Konkuk University School of Medicine) ;
  • Cho, Suk Kyung (Department of Pediatrics, Konkuk University School of Medicine) ;
  • Park, Yong-Mean (Department of Pediatrics, Konkuk University School of Medicine) ;
  • Lee, Ran (Department of Pediatrics, Konkuk University School of Medicine) ;
  • Chung, Sochung (Department of Pediatrics, Konkuk University School of Medicine) ;
  • Bae, Sun Hwan (Department of Pediatrics, Konkuk University School of Medicine,)
  • 유정진 (건국대학교 의학전문대학원 소아과학교실) ;
  • 조숙경 (건국대학교 의학전문대학원 소아과학교실) ;
  • 박용민 (건국대학교 의학전문대학원 소아과학교실) ;
  • 이란 (건국대학교 의학전문대학원 소아과학교실) ;
  • 정소정 (건국대학교 의학전문대학원 소아과학교실) ;
  • 배선환 (건국대학교 의학전문대학원 소아과학교실)
  • Received : 2007.12.17
  • Accepted : 2008.05.18
  • Published : 2008.06.15
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Abstract

Purpose : This study was designed to investigate normal domestic values for the diameter of the left main coronary artery (LCA), the left anterior descending coronary artery (LAD) and the right coronary artery (RCA). These data are necessary to define dilatation of coronary arteries in Kawasaki disease cases. Methods : Study subjects were 43 normal healthy children whose ages ranged from 3 months to 6 years. They children visited Konkuk University hospital for echocardiograph examination between March 2005 and November 2007. Measurements of coronary arterial diameters at each branch were done by off-line analyses of recorded images. Simple regression analysis of each the measurements were performed using the body size (body surface area, etc.) as the independent variable. Results : Body surface area was significantly related to the diameters of LCA ($r^2=0.20$, P=0.0038), of LAD ($r^2=0.41$, P<0.0001), and of RCA ($r^2=0.30$, P=0.0002). In the regression model, the estimates of the y-intercept were 1.703, 1.058, and 1.007; the estimates of the regression coefficient were 0.971, 1.175, and 1.177; and the estimates of the standard deviation were 0.315, 0.221, and 0.282 with respect to the three coronary arteries. Conclusion : A the linear regression model of the diameters of three coronary arteries adjusted for body surface area was produced. With these results, the Z-score calculation of the diameter of three coronary arteries, based on normal domestic data, will be possible.

목 적 : 가와사끼병에 따른 관상동맥 직경 증가를 판단하기 위하여 필요한 좌주간부 관상동맥(LCA, left main coronary artery), 좌전하행 관상동맥(LAD, left anterior desending coronary artery), 우 관상동맥(RCA, right coronary artery) 각각의 정상 직경에 대한 자료가 아직 국내에 발표되지 않아, 이를 조사하기 위해 본 연구가 계획되었다. 방 법 : 2005년 3월부터 2007년 11월까지 건국대학교 병원을 방문하여 심초음파 검사를 받았으나, 특별한 심질환 소견을 보이지 않았던 생후 3개월에서 7세 미만 소아 43명을 대상으로 하였다. 심초음파 검사 시행 후 저장되었던 영상 자료에서 관상동맥 크기 측정이 이루어졌으며, 체표면적 등의 몸 크기 자료를 독립 변수로 하여 단순 선형 회귀분석이 시행되었다. 결 과 : 체표면적은 LCA($R^2=0.20$, P=0.0038), LAD($R^2=0.41$, P<0.0001), 및 RCA($R^2=0.30$, P=0.0002) 모두의 직경과 의미 있는 관계를 보였다. 회귀 공식에서 y 절편은 각각 1.703, 1.058, 1.007; 회귀 계수는 각각 0.971, 1.175, 1.177; 표준편차는 각각 0.315, 0.221, 0.282 로 추정되었다. 결 론 : 개별 관상동맥 직경과 체표면적과의 의미 있는 관계가 확인되었고, 선형 회귀 공식이 산출되었다. 본 연구 결과를 활용하여, 개별 관상동맥 직경의 Z-score 산출을 국내 자료로서 가능하도록 한 것이 본 연구의 의의라고 할 수 있겠다.

Keywords

References

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  1. Perivascular Brightness of Coronary Arteries in Kawasaki Disease vol.159, pp.3, 2008, https://doi.org/10.1016/j.jpeds.2011.02.029