과제정보
연구 과제 주관 기관 : Chonnam National University
참고문헌
- Agerholm-Larsen, B., Nordestgaard, B.G., Steffensen, R., Jensen, G., and Tybjaerg-Hansen, A. (2000). Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene. Circulation 101, 1907-1912 https://doi.org/10.1161/01.CIR.101.16.1907
- Barzilai, N., Atzmon, G., Schechter, C., Schaefer, E.J., Cupples, A.L., Lipton, R., Cheng, S., and Shuldiner, A.R. (2003). Unique lipoprotein phenotype and genotype associated with exceptional longevity. Jama 290, 2030-2040 https://doi.org/10.1001/jama.290.15.2030
- Blankenberg, S., Rupprecht, H.J., Bickel, C., Jiang, X.C., Poirier, O., Lackner, K.J., Meyer, J., Cambien, F., and Tiret, L. (2003). Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery disease. J. Am. Coll. Cardiol. 41, 1983-1989 https://doi.org/10.1016/S0735-1097(03)00408-X
- Claudel, T., Sturm, E., Duez, H., Torra, I.P., Sirvent, A., Kosykh, V., Fruchart, J.C., Dallongeville, J., Hum, D.W., Kuipers, F., et al. (2002). Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. J. Clin. Invest. 109, 961-971 https://doi.org/10.1172/JCI0214505
- Claudel, T., Inoue, Y., Barbier, O., Duran-Sandoval, D., Kosykh, V., Fruchart, J., Fruchart, J.C., Gonzalez, F.J., and Staels, B. (2003). Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology 125, 544-555 https://doi.org/10.1016/S0016-5085(03)00896-5
- de Grooth, G.J., Zerba, K.E., Huang, S.P., Tsuchihashi, Z., Kirchgessner, T., Belder, R., Vishnupad, P., Hu, B., Klerkx, A.H., Zwinderman, A.H., et al. (2004). The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome: a prospective analysis of the CETP TaqIB polymorphism on cardiovascular out come and interaction with cholesterol-lowering therapy. J. Am. Coll. Cardiol. 43, 854-857 https://doi.org/10.1016/j.jacc.2003.08.056
- del Castillo-Olivares, A., and Gil, G. (2000). Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydro-xylase transcription. Nucleic Acids Res. 28, 3587-3593 https://doi.org/10.1093/nar/28.18.3587
- Forman, B.M., Goode, E., Chen, J., Oro, A.E., Bradley, D.J., Perlmann, T., Noonan, D.J., Burka, L.T., McMorris, T., Lamph, W.W., et al. (1995). Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81, 687-693 https://doi.org/10.1016/0092-8674(95)90530-8
- Giguere, V. (1999). Orphan nuclear receptors: from gene to function. Endocr. Rev. 20, 689-725 https://doi.org/10.1210/er.20.5.689
- Goodwin, B., Jones, S.A., Price, R.R., Watson, M.A., McKee, D.D., Moore, L.B., Galardi, C., Wilson, J.G., Lewis, M.C., Roth, M.E., et al. (2000). A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell 6, 517-526 https://doi.org/10.1016/S1097-2765(00)00051-4
- Hanniman, E.A., Lambert, G., McCarthy, T.C., and Sinal, C.J. (2005). Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice. J. Lipid Res. 46, 2595- 2604 https://doi.org/10.1194/jlr.M500390-JLR200
- Kim, E., Xie, S., Yeh, S.D., Lee, Y.F., Collins, L.L., Hu, Y.C., Shyr, C.R., Mu, X.M., Liu, N.C., Chen, Y.T., et al. (2003). Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster. J. Biol. Chem. 278, 46919-46926 https://doi.org/10.1074/jbc.M304088200
- Kim, E., Yang, Z., Liu, N.C., and Chang, C. (2005). Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region. Biochem. Biophys. Res. Commun. 328, 85-90 https://doi.org/10.1016/j.bbrc.2004.12.146
- Laffitte, B.A., Kast, H.R., Nguyen, C.M., Zavacki, A.M., Moore, D.D., and Edwards, P.A. (2000). Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. J. Biol. Chem. 275, 10638-10647 https://doi.org/10.1074/jbc.275.14.10638
- Lambert, G., Amar, M.J., Guo, G., Brewer, H.B. Jr., Gonzalez, F.J., and Sinal, C.J. (2003). The farnesoid X-receptor is an essential regulator of cholesterol homeostasis. J. Biol. Chem. 278, 2563-2570 https://doi.org/10.1074/jbc.M209525200
- Lu, T.T., Makishima, M., Repa, J.J., Schoonjans, K., Kerr, T.A., Auwerx, J., and Mangelsdorf, D.J. (2000). Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. 6, 507-515 https://doi.org/10.1016/S1097-2765(00)00050-2
- Luo, Y., and Tall, A.R. (2000). Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J. Clin. Invest. 105, 513-520 https://doi.org/10.1172/JCI8573
-
Luo, Y., Liang, C.P., and Tall, A.R. (2001). The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver
$\times$ receptor. J. Biol. Chem. 276, 24767-24773 https://doi.org/10.1074/jbc.M100912200 - Makishima, M., Okamoto, A.Y., Repa, J.J., Tu, H., Learned, R.M., Luk, A., Hull, M.V., Lustig, K.D., Mangelsdorf, D.J., and Shan, B. (1999). Identification of a nuclear receptor for bile acids. Science 284, 1362-1365 https://doi.org/10.1126/science.284.5418.1362
- Parks, D.J., Blanchard, S.G., Bledsoe, R.K., Chandra, G., Consler, T.G., Kliewer, S.A., Stimmel, J.B., Willson, T.M., Zavacki, A.M., Moore, D.D., et al. (1999). Bile acids: natural ligands for an orphan nuclear receptor. Science 284, 1365-1368 https://doi.org/10.1126/science.284.5418.1365
- Sinal, C.J., Tohkin, M., Miyata, M., Ward, J.M., Lambert, G., and Gonzalez, F.J. (2000). Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102, 731- 744 https://doi.org/10.1016/S0092-8674(00)00062-3
- Sperker, B., Mark, M., and Budzinski, R.M. (1993). The expression of human plasma cholesteryl-ester-transfer protein in HepG2 cells is induced by sodium butyrate. Quantification of low mRNA levels by polymerase chain reaction. Eur. J. Biochem. 218, 945-950 https://doi.org/10.1111/j.1432-1033.1993.tb18451.x
- Watanabe, M., Houten, S.M., Wang, L., Moschetta, A., Mangelsdorf, D.J., Heyman, R.A., Moore, D.D., and Auwerx, J. (2004). Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J. Clin. Invest. 113, 1408-1418 https://doi.org/10.1172/JCI21025
- Willy, P.J., Umesono, K., Ong, E.S., Evans, R.M., Heyman, R.A., and Mangelsdorf, D.J. (1995). LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9, 1033-1045 https://doi.org/10.1101/gad.9.9.1033
- Zhang, Y., Wang, X., Vales, C., Lee, F.Y., Lee, H., Lusis, A.J., and Edwards, P.A. (2006). FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice. Arterioscler. Thromb. Vasc. Biol. 26, 2316-2321 https://doi.org/10.1161/01.ATV.0000235697.35431.05