Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
권호 표지
DOI QR코드

DOI QR Code

Once daily dosing of aminoglycoside in children

소아에서 aminoglycoside의 1일 1회 요법

  • Shin, Seon Hee (Department of Pediatrics, College of Medicine, Hallym University)
  • 신선희 (한림대학교 의과대학 소아과학교실)
  • Received : 2008.08.25
  • Accepted : 2008.09.05
  • Published : 2008.10.15
Download PDF
⟨ Previous Next ⟩

Abstract

Aminoglycosides are frequently used antibiotics in children. The multiple daily dosing (MDD) in infants and children is twice or three times daily depending on age. Recent studies in adults have shown that once daily dosing (ODD) maximizes the bactericidal activity and might minimize the toxicity of antibiotics. So, I reviewed many studies about efficacy, toxicity and cost effectiveness of ODD of aminoglycosides in children. Most studies suggest that ODD compared with MDD of aminoglycosides is theoretically more efficacious and has no higher toxicity in infants and children. But, the total number of patients included in the studies is not large. Multi-center, controlled prospective studies are required in larger numbers of infants and children to determine the efficacy and safety of the ODD regimen in children before ODD of aminoglycosides can be recommended for routine use.

Keywords

References

  1. John JF Jr. What price success? the continuing saga of the toxic: therapeutic ratio in the use of aminoglycoside antibiotics. J Infect Dis 1988;158:1-6 https://doi.org/10.1093/infdis/158.1.1
  2. Lacy MK, Nicolau DP, Nightingale CH, Quintiliani R. The pharmacodynamics of aminoglycosides. Clin Infect Dis 1998;27:23-7 https://doi.org/10.1086/514620
  3. MacKenzie FM, Gould IM. The post-antibiotic effect. J Antimicrob Chemother 1993;32:519-37 https://doi.org/10.1093/jac/32.4.519
  4. Parker SE, Davey PG. Practicalities of once-daily aminoglycoside dosing. J Antimicrob Chemother 1993;31:4-8 https://doi.org/10.1093/jac/31.1.4
  5. Prins JM, Buller HR, Kuijper EJ, Tange RA, Speelman P. Once versus thrice-daily gentamicin in patients with serious infections. Lancet 1993;341:335-9 https://doi.org/10.1016/0140-6736(93)90137-6
  6. Bailey TC, Little JR, Littenberg B, Reichley RM, Dunagen WC. A meta-analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides. Clin Infect Dis 1997;24:786-95 https://doi.org/10.1093/clinids/24.5.786
  7. Levison ME. Pharmacodynamics of antimicrobial agents. Bactericidal and postantibiotic effects. Infect Dis Clin North Am 1995;9:483-95
  8. Logsdon BA, Phelps SJ. Routine monitoring of gentamicin serum concentrations in pediatric patients with normal renal function is unnecessary. Ann Pharmacother 1997;31:1514-8 https://doi.org/10.1177/106002809703101212
  9. Smyth AR, Tan KH. Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis. Cochrane Database Syst Rev 2006;19:3:CD002009
  10. Buijk SE, Mouton JW, Gyssens IC, Verbrugh HA, Bruining HA. Experience with once-daily dosing program of aminoglycosides in critically ill patients. Intensive Care Med 2002; 28:936-42 https://doi.org/10.1007/s00134-002-1313-7
  11. Nicolau DP, Wu AH, Finocchiaro S, Udeh E, Chow MS, Quintiliani R, et al. Once-daily aminoglycoside dosing. Impact on requests and costs for therapeutic drug monitoring. Ther Drug Monit 1996;18:263-6 https://doi.org/10.1097/00007691-199606000-00007
  12. Craig WA. Once-daily versus multiple-day dosing of aminoglycosides. J Chemother 1995;7:S47-52
  13. Hatala R, Dinh T, Cook DJ. Once-daily aninoglycoside dosing in immunocompetent adults: a meta-analysis. Ann Intern Med 1996;124:717-25 https://doi.org/10.7326/0003-4819-124-8-199604150-00003
  14. Chuck SK, Raber SR, Rodvold KA, Areff D. National survey of extended-interval aminoglycoside dosing. Clin Infect Dis 2000;30:433-9 https://doi.org/10.1086/313692
  15. Contopoulus-Ioannidis DG, Giotis ND, Baliata DV, Joannidis JPA. Extended-interval aminoglycoside administration for children : A meta-analysis. Pediatrics 2004;114:e111-8 https://doi.org/10.1542/peds.114.1.e111
  16. Vigano A, Principi N, Brivio L, Tommasi P, Stasi P, Villa AD. Comparison 5 mg/kg of netilmicin once daily vs. 2 mg/ kg thrice daily for treatment of gram-negative pyelonephritis in children. Antimicrob Agents Chemother 1993;36:1499-503
  17. Skopnik H, Wallraf R, Nies B, Troster K, Heimann G. Pharmacokinetics and antibacterial activity of daily gentamicin. Arch Dis Child 1992;67:57-61 https://doi.org/10.1136/adc.67.1_Spec_No.57
  18. Elhanan K, Siplovich L, Raz R. Gentamicin once-daily versus thrice-daily in children. J Antimicrob Chemother 1995; 35:327-32 https://doi.org/10.1093/jac/35.2.327
  19. Fattinger K, Vozeh S, Olafasson A, Vicek J, Wenk M, Follath F. Netilmicin in the neonate: population pharmacokinetic analysis and dosing recommendations. Clin Pharmacol Ther 1991;50:55-65 https://doi.org/10.1038/clpt.1991.103
  20. Bass KD, Larkin SE, Paap C, Haase GM. Pharmacokientics of once-daily dosing of gentamicin in pediatric patients. J Pediatr Surg 1998;33:1104-7 https://doi.org/10.1016/S0022-3468(98)90540-1
  21. Postovsky S, Ben Arush MW, Kassis E, Elhasid R, Krivoy N. Pharmacokinetic analysis of gentamicin thrice and single daily dosage in pediatric cancer patients. Pediatr Hematol Oncol 1997;14:547-54 https://doi.org/10.3109/08880019709030911
  22. Hayani KC, Hatzopoulos FK, Fank AL, Thummala MR, Hantsch MJ, Schatz BM, et al. Pharmacokinetics of oncedaily dosing of gentamicin in neonates. J Pediatr 1997;131: 76-80 https://doi.org/10.1016/S0022-3476(97)70127-6
  23. Ali MZ, Goetz MB. A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides. Clin Infect Dis 1997;24:796-809 https://doi.org/10.1093/clinids/24.5.796
  24. Galloe AM, Graudal N, Christensen HR, Kampmann JP. Aminoglycosides: single or multiple daily dosing? A metaanalysis on efficacy and safety. Eur J Clin Pharmacol 1995; 48:39-93
  25. Miran D. Once daily dosing of gentamicin in infants and children. Pediatr Infect Dis J 2001;20:1169-73 https://doi.org/10.1097/00006454-200112000-00016
  26. Carapetis JR, Jaquiery AK, Buttery JP, Starr M, Cranswick NE, Kohn S, et al. Randomized, controlled trial comparing once daily and three times daily gentamicin in children with urinary tract infection. Pediatr Infect Dis J 2001;20:240-6 https://doi.org/10.1097/00006454-200103000-00004
  27. Giapros VI, Andronikou SK, Cholevas VI, Papadopoulous ZL. Renal function and effect of aminoglycoside therapy during the first ten days of life. Pediatr Nephrol 2003;18:46-52 https://doi.org/10.1007/s00467-002-1001-4
  28. Thureen PJ, Reiter PD, Gresores A, Stolpman NM, Kawato K, Hall DM, Once versus twice daily gentamicin dosing in neonates $\geq$34 weeks' gestation: cost-effectiveness analysis. Pediatrics 1999;103:594-8 https://doi.org/10.1542/peds.103.3.594