Asian-Australasian Journal of Animal Sciences

  • 제21권10호
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  • Pages.1473-1478
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  • 2008
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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The Growth-promoting Effect of Tetrabasic Zinc Chloride is Associated with Elevated Concentration of Growth Hormone and Ghrelin

  • Zhang, Bingkun (State Key Lab of Animal Nutrition, College of Animal Science and Technology China Agricultural University) ;
  • Guo, Yuming (State Key Lab of Animal Nutrition, College of Animal Science and Technology China Agricultural University)
  • 투고 : 2008.01.23
  • 심사 : 2008.04.16
  • 발행 : 2008.10.01
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초록

An experiment was conducted to investigate the mechanism for the effect of tetrabasic zinc chloride (TBZC) in enhancing growth performance of weanling piglets. Gut-brain peptides play an important role in the regulation of growth and appetite in animals. This study evaluated the effects of TBZC on blood concentrations of growth hormone (GH), ghrelin, insulin-like growth factor-I (IGF-I), cholecystokinin (CCK) and neuropeptide Y (NPY). Seventy-two weanling piglets (Landrace$\times$Large White) with an initial body weight (BW) of $6.7{\pm}0.16kg$ and aged $24{\pm}1days$ were assigned to three dietary treatments: i) control diet without TBZC supplement, ii) the control diet supplemented with 2,000 mg Zn from TBZC/kg and iii) TBZC-supplemented diet pair-fed with respect to the control diet. Each treatment had six replications (pens) of four piglets. At the end of a 14-d experimental period, piglets were weighed and feed consumption was measured, and blood samples were collected for assays of GH, ghrelin, IGF-I, CCK and NPY concentrations. The inclusion of TBZC in the diet increased average daily gain (p<0.01), average daily feed intake (p<0.05), and feed conversion ratio (p<0.05). Pair-fed piglets had higher ADG, and lower FCR than (p<0.05) Control piglets. Supplementation of the diet with TBZC increased (p<0.05) serum GH and plasma ghrelin levels in weanling piglets, but did not affect (p>0.05) serum IGF-I and plasma NPY and CCK concentrations. Pair-fed piglets had lower (p<0.05) serum GH levels than TBZC-supplemented piglets, but did not (p>0.05) differ from Control piglets. These data indicated that TBZC elevated the concentration of ghrelin and GH. This observation may partly explain the beneficial effects of TBZC on growth performance of weanling piglets.

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참고문헌

  1. Bauer-Dantoin, A. C., J. K. McDonald and J. E. Levine. 1991. Neuropeptide Y potentiates luteinizing hormone (LH) releasing hormone-stimulated LH surges in pentobarbital proestrus rats. Endocrinol. 129:402-408. https://doi.org/10.1210/endo-129-1-402
  2. Bhatti, S. F., L. M. Ham, J. A. van Mol and H. S. Kooistra. 2006. Ghrelin, an endogenous growth hormone secretagogue with diverse endocrine and nonendocrine effects. Am. J. Vet. Res. 67:180-188. https://doi.org/10.2460/ajvr.67.1.180
  3. Carlson, D., H. D. Poulsen and M. Vestergaard. 2004. Additional dietary zinc for weaning piglets is associated with elevated concentrations of serum IGF-I. J. Anim. Physiol. Anim. Nutr. 88:332-339. https://doi.org/10.1111/j.1439-0396.2004.00488.x
  4. Carlson, M. S., G. M. Hill and J. E. Link. 1999. Early- and traditionally weaned nursery pigs benefit from phase-feeding pharmacological concentrations of zinc oxide: Effect on metallothionein and mineral concentrations. J. Anim. Sci. 77: 1199-1207. https://doi.org/10.2527/1999.7751199x
  5. Case, C. L. and M. S. Carlson. 2002. Effect of feeding organic and inorganic sources of additional zinc on growth performance and zinc balance in nursery pigs. J. Anim. Sci. 80:1917-1924. https://doi.org/10.2527/2002.8071917x
  6. Clark, R. G., L. M. S. Carlsson, D. Mortensen and M. J. Cronin. 1994. Additive effects on body growth of insulin-like growth factor-l and growth hormone in hypophysectomized rats. Endocrinol. Metab. 1:49-54.
  7. Daughaday, W. H., I. K. Mariz and S. L. Blethen. 1980. Inhibition of access of basic somatomedin to membrane receptors and immunobinding sites: A comparison of radioreceptor and radioimmunological somatomedin in native and acid ethanol extracted serum. J. Clin. Endocr. Metab. 51:781-788. https://doi.org/10.1210/jcem-51-4-781
  8. Guler, H. P., J. Zapf, E. Scheiwiller and E. R. Froesch. 1988. Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomizrd rats. Proc. Natl. Acad. Sci. 85:4889-4893. https://doi.org/10.1073/pnas.85.13.4889
  9. Hahn, J. D. and D. H. Bake. 1993. Growth and plasma zinc responses of young pig fed pharmacologic levels of zinc. J. Anim. Sci. 71:3020-3024. https://doi.org/10.2527/1993.71113020x
  10. Havel, P. J. 2001. Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp. Biol. Med. 226: 963-977. https://doi.org/10.1177/153537020122601102
  11. Huda, M. S. B., J. P. H. Wilding and J. H. Pinkney. 2006. Gut peptides and the regulation of appetite. Obesity Reviews. 7: 163-182. https://doi.org/10.1111/j.1467-789X.2006.00245.x
  12. Kojima, M. and K. Kangawa. 2005. Ghrelin: structure and function. Physiol. Rev. 85:495-522. https://doi.org/10.1152/physrev.00012.2004
  13. Kojima, M., H. Hosoda, Y. Date, M. Nakazato, H. Matsuo and K. Kangawa. 1999. Ghrelin is a growth-hormone releasing acylated peptide from stomach. Nature 402:656-660. https://doi.org/10.1038/45230
  14. Li, X., J. Yin, D. Li, X. Chen, J. Zang and X. Zhou. 2006. Dietary supplementation with zinc oxide increases IGF-I and IGF-I receptor gene expression in the small intestine of weaning piglets. J. Nutr. 136:1786-1791. https://doi.org/10.1093/jn/136.7.1786
  15. Mavromichalis, I., D. M. Webel, E. N. Parr and D. H. Baker. 20001. Growth-promoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs. Can. J. Anim. Sci. 81: 387-391.
  16. National Research Council. 1998. Nutrient Requirements of Swine. 10th Ed. National Academic Press, Washington, DC.
  17. Poulsen, H. D. 1995. Zinc oxide for weanling piglets. Acta Agric. Scand. A: Anim. Sci. 45:159-167.
  18. Rosenfeld, R. G. and C. T. J. Roberts. 1999. The IGF system: molecular biology, physiology, and clinical applications. Humana Press, Totowa. NJ.
  19. Schell, T. C. and E. T. Kornegay. 1994. Effectiveness of zinc acetate injection in alleviating postweaning performance lag in pigs. J. Anim. Sci. 72:3037-3042. https://doi.org/10.2527/1994.72123037x
  20. Sjogren, K., J. L. Liu, K. Blad, S. Skrtic, O. Vidal, V. Wallenius, D. Leroith, J. Tornell, O. G. P. Isaksson, J. Jansson and C. Ohlsson. 1999. Liver-derived insulin-like growth factor I (IGFI) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc. Natl. Acad. Sci. 96:7088-7092. https://doi.org/10.1073/pnas.96.12.7088
  21. Stanley, B. G. and S. F. Leibowitz. 1985. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Pro. Natl. Acad. Sci. 82:3940-3943. https://doi.org/10.1073/pnas.82.11.3940
  22. Swamy, H. V., T. K. Smith and E. J. MacDonald. 2004. Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on brain regional neurochemistry of starter pigs and broiler chickens. J. Anim. Sci. 82: 2131-2139. https://doi.org/10.2527/2004.8272131x
  23. Tschop, M., D. L. Smiley and M. L. Heiman. 2000. Ghrelin induces adiposity in rodents. Nature 407:908-913. https://doi.org/10.1038/35038090
  24. Wallenius, K. S., X. D. Peng, S. Park, V. Wallenius, J. L. Liu, M. Umaerus, H. Wennbo, O. Isaksson, L. Frohman, R. Kineman, C. Ohlsson and J. O. Jansson. 2001. Liver-derived IGF-I regulates GH secretion at the pituitary level in mice. Endocrinol. 142:4762-4770. https://doi.org/10.1210/en.142.11.4762
  25. Wang, Z., Y. Guo, J. Yuan and B. Zhang. 2008. Effect of dietary $\beta$ -1,3/1,6-glucan supplementation on growth performance, immune response and plasma prostaglandin E2, growth hormone and ghrelin in weanling piglets. Asian-Aust. J. Anim. Sci. 21:707-714. https://doi.org/10.5713/ajas.2008.70559
  26. Wu, X., M. Tang, Q. Ma, X. Hu and C. Ji. 2008. Effects of exogenous ghrelin on the behaviors and performance of weanling piglets. Asian-Aust. J. Anim. Sci. 21:861-867. https://doi.org/10.5713/ajas.2008.70574
  27. Yakar, S., J. L. Liu, B. Stannard, A. Butler, D. Accili and B. Sauer. 1999. Normal growth and development in the absence of hepatic insulin like growth factor I. PNAS. 96:7324-7329. https://doi.org/10.1073/pnas.96.13.7324
  28. Zhang, B. and Y. Guo. 2007. Beneficial effects of tetrabasic zinc chloride for weanling piglets and the bioavailability of zinc in tetrabasic form relative to ZnO. Anim. Feed. Sci. Tech. 135:75-85. https://doi.org/10.1016/j.anifeedsci.2006.06.006

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