Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Seasonal Change of Plasma Free Amino Acids with Special Reference to 3-Methylhistidine in Racehorses

  • Sawada, Kumiko (DSM Nutrition Japan K.K.) ;
  • Li, Jun You (Animal Resource Science Center, Graduate School of Agricultural and Life Science, The University of Tokyo) ;
  • Kuribayashi, Yasuko (Tanabe Racehorses Clinic) ;
  • Itabashi, Hisao (Faculty of Applied Life Science, Nippon Veterinary and Life Science University)
  • Received : 2008.03.24
  • Accepted : 2008.07.16
  • Published : 2008.12.01
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Abstract

Seasonal changes in the concentration of free amino acids were determined monthly in plasma from the jugular blood of 50 thoroughbred racehorses that compete during the night between June and September and during the day between October and January. The concentration of most free amino acids remained relatively constant between June and January. However, those of glutamic acid, alanine, isoleucine and lysine tended to decrease and that of arginine (Arg) significantly decreased between July and September. The concentration of methionine (Met) gradually increased between June and September and significantly decreased thereafter. The concentration of 3-methylhistidine (3-MH) significantly increased between July and September and decreased thereafter. There were significant correlation between 3-MH and Arg. In conclusion, this study provided evidence of significant seasonal change in plasma 3-MH, Arg and Met of racehorses, and this was considered to relate to an environmental effect. Moreover, our study is the first to show 3-MH in plasma of racehorses affected by environmental change.

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References

  1. Balnave, D. and A. G. Oliva. 1991. The influence of $NaHCO_3$ and sulfur amino acids on the performance of broilers at moderate and high temperatures. Aust. J. Agric. Res. 42:1385-1397. https://doi.org/10.1071/AR9911385
  2. Blum, J. W. and T. Reding. 1985. Variations of 3-methylhistidine in blood of dairy cows. J. Dairy Sci. 68:2580-3587. https://doi.org/10.3168/jds.S0022-0302(85)81140-1
  3. Brake, J., D. Balnave and J. J. Dibner. 1998. Optimum dietary arginine: lysine ratio for broiler chickens is altered during heat stress in association with changes in intestinal uptake and dietary sodium chloride. Br. Poult. Sci. 39:639-647. https://doi.org/10.1080/00071669888511
  4. DePew, C. L., D. L. Thompson, J. M. Fernandez, L. S. Sticker and D. W. Burleigh. 1994. Changes in concentrations of hormones, metabolites, and amino acids in plasma of adults horses relative to overnight feed deprivation followed by a pellet-hay meal fed at noon. J. Anim. Sci. 72:1530-1539. https://doi.org/10.2527/1994.7261530x
  5. Doepel, L., H. Lapierre and J. J. Kennelly. 2002. Peripartum performance and metabolism of dairy cows in response to prepartum energy and protein intake. J. Dairy Sci. 85:2315-2334. https://doi.org/10.3168/jds.S0022-0302(02)74312-9
  6. Equine Research Institute, Japan Racing Association. 1998. Japanese Feeding Standard for Horses 1st Ed. 17-47. Animal Media Ltd. Tokyo.Press, Tokyo, Japan.
  7. Harris, C. I. and G. Milne. 1981. The urinary excretion of $N^{\tau}$- methylhistidine by cattle: validation as an index of muscle protein breakdown. Br. J. Nutr. 45:411-422. https://doi.org/10.1079/BJN19810116
  8. Harris, C. I. 1981. Reappraisal of the quantitative importance of non-skeletal muscle source of $N^{\tau}$-methylhistidine in urine. Biochem. J. 194:1011-1014. https://doi.org/10.1042/bj1941011
  9. Harris, C. I. and G. Milne. 1981. The inadequacy of urinary $N^{\tau}$-methyl histidine excretion in the pig as a measure of muscle protein breakdown. Br. J. Nutr. 45:423-429. https://doi.org/10.1079/BJN19810117
  10. Harris, C. I. and G. Milne. 1980. The urinary excretion of $N^{\tau}$-methyl histidine in sheep: an invalid index of muscle protein breakdown. Br. J. Nutr. 44:129-140. https://doi.org/10.1079/BJN19800020
  11. Johnson, R. J. and J. W. Hart. 1974. Influence of feeding and fasting on plasma free amino acids in the equine. J. Anim. Sci. 38:790-794. https://doi.org/10.2527/jas1974.384790x
  12. Kamiya, M., Y. Kamiya, M. Tanaka, T. Oki, Y. Nishiba and S. Shioya. 2006. Effect of high ambient temperature and restricted feed intake on urinary and plasma 3-methylhistidine in lactating Holstein cows. Anim. Sci. J. 77:201-207. https://doi.org/10.1111/j.1740-0929.2006.00338.x
  13. Kamiya, M., Y. Kamiya, M. Tanaka and S. Shioya. 2006. Milk protein production and plasma 3-methylhistidine concentration in lactating Holstein cows exposed to high ambient temperatures. Asian-Aust. J. Anim. Sci. 19:1159-1163. https://doi.org/10.5713/ajas.2006.1159
  14. Kocen, J. A., J. E. Wohlt and W. L. Foy. 1982. Dietary intake and routes of excretion of 3-methylhistidine in lactating dairy cattle. J. Anim. Sci. 55(Suppl.1):435(Abstr.).
  15. Long, C. L., L. N. Haververg, Y. R. Young, J. M. Kinney, H. M. Munro and J. W. Geiger. 1975. Metabolism of 3-methylhistidine in man. Metabolism: clinical and experimental 24:929-935. https://doi.org/10.1016/0026-0495(75)90084-0
  16. Motyl, T. and W. Barej. 1986. Plasma amino acid indices and urinary 3-methyl histidine excretion in dairy cows in early lactation. Ann. Rech. Vet. 17(2):153-157.
  17. Nishizawa, N. and H. Itabashi. 1984. Measurement of synthetic and catabolic rates of skeletal muscle protein by using 3-methylhistidine method and its application. Proceeding of Japanese Society for Animal Nutrition and Metabolism 28(2):97-110.
  18. Nishizawa, N., M. Shimbo and S. Harayama. 1977. Fractional catabolic rates of myosin and actin estimated by urinary excretion of $N^{\tau}$-methylhistidine: the effect of dietary protein level on catabolic rates under conditions of restricted food intake. Br. J. Nutr. 37:345-353. https://doi.org/10.1079/BJN19770038
  19. Nishizawa, N., Y. Toyoda, T. Noguchi, S. Hareyama, H. Itabashi. and R. Funabiki. 1979. $N^{\tau}$-methylhistidine content of organs and tissues of cattle and an attempt to estimate fractional catabolic and synthetic rates of myofibrillar protein of skeletal muscle during growth by measuring urinary output of $N^{\tau}$- methylhistidine. Br. J. Nutr. 42:247-252. https://doi.org/10.1079/BJN19790111
  20. Nishizawa, N., S. Igarashi, H. Itabashi and S. Harayama. 1989. Urinary excretion of $N^{\tau}$-methylhistidine in goat. Nutrition Report International 40:567-576.
  21. Russell, M. A., A. V. Rodiek and L. M. Lawrence. 1986. Effect of meal schedules and fasting on selected plasma free amino acids in horses. J. Anim. Sci. 63:1428-1431. https://doi.org/10.2527/jas1986.6351428x
  22. Young, V. R. and H. N. Munro. 1978. $N^{\tau}$-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview. Fed. Proc. 37(9):2291-2300.
  23. Young, V. R., S. D. Alexis, B. S. Baliga, H. N. Munro and W. Muecke. 1972. Metabolism of administered 3-methylhistidine. Lack of muscle transfer ribonucleic acid charging and quantitative excretion as 3-methylhistidine and its N-acetyl derivative. J. Biol. Chem. 247:3592-3600.