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외상후 척수공동증 환자에서 Ketamine 정주요법에 의한 치료 경험

Ketamine Infusion Therapy in a Patient of Posttraumatic Syringomyelia

  • 정일 (울산대학교 의과대학 강릉아산병원 마취통증의학교실) ;
  • 김영기 (울산대학교 의과대학 강릉아산병원 마취통증의학교실) ;
  • 강명수 (울산대학교 의과대학 강릉아산병원 마취통증의학교실) ;
  • 서민교 (울산대학교 의과대학 강릉아산병원 마취통증의학교실) ;
  • 이청 (을지대학교 의과대학 마취통증의학교실)
  • Jung, Il (Department of Anesthesiology and Pain Medicine, Gangneung Asan Medical Center, University of Ulsan Collage of Medicine) ;
  • Kim, Young Ki (Department of Anesthesiology and Pain Medicine, Gangneung Asan Medical Center, University of Ulsan Collage of Medicine) ;
  • Kang, Myong Soo (Department of Anesthesiology and Pain Medicine, Gangneung Asan Medical Center, University of Ulsan Collage of Medicine) ;
  • Suh, Min Kyo (Department of Anesthesiology and Pain Medicine, Gangneung Asan Medical Center, University of Ulsan Collage of Medicine) ;
  • Lee, Cheong (Department of Anesthesiology and Pain Medicine, Eulji University School of Medicine)
  • 투고 : 2008.09.23
  • 심사 : 2008.11.04
  • 발행 : 2008.12.30

초록

The clinical syndrome of posttraumatic syringomyelia can complicate major spinal trauma and develops many months after spinal injury. The 50-90% of patients experienced the pain and especially the component of central pain. In patients with central pain following spinal cord injury, ketamine has been shown to be an effective analgesic. We report a case of posttraumatic syringomyelia in a 30-year-old woman who complained of central pain, weakness of both legs and dysesthesia. She had not responded to pulsed radiofrequency, or lidocaine infusion therapy, but a continuous intravenous infusion of ketamine, an N-methyl-D-asparate receptor antagonist, reduced her severe central pain. In conclusion, a ketamine infusion therapy resulted in a significant reduction of central pain without decreasing of motor power and function.

키워드

참고문헌

  1. Barnett HJ, Jousse AT: Posttraumatic syringomyelia (cystic myelopathy). Handb Clin Neurol 1976; 26: 113-57
  2. Gamache FW Jr, Ducker TB: Syringomyelia: a neurological and surgical spectrum. J Spinal Disord 1990; 3: 293-8
  3. Eide PK, Stubhaug A, Stenehjem AE: Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. Neurosurgery 1995; 37: 1080-7 https://doi.org/10.1227/00006123-199512000-00007
  4. Barbaro NM, Wilson CB, Gutin PH, Edwards MS: Surgical treatment of syringomyelia. Favorable results with syringo-peritoneal shunting. J Neurosurg 1984; 61: 531-8 https://doi.org/10.3171/jns.1984.61.3.0531
  5. Umbach I, Heilporn A: Review article: post-spinal cord injury syringomyelia. Paraplegia 1991; 29: 219-21 https://doi.org/10.1038/sc.1991.32
  6. Grant R, Hadley DM, Macpherson P, Condon B, Patterson J, Bone I, et al: Syringomyelia: cyst measurement by magnetic resonance imaging and comparison with symptoms, signs and disability. J Neurol Neurosurg Psychiatry 1987; 50: 1008-14 https://doi.org/10.1136/jnnp.50.8.1008
  7. Sgouros S, Williams B: Management and outcome of posttraumatic syringomyelia. J Neurosurg 1996; 85: 197-205 https://doi.org/10.3171/jns.1996.85.2.0197
  8. Bohlman HH, Ducker TB, Lucas JT: Spine and spinal cord injury. In: The spine. 2nd ed. Edited by Rothman RH, Simeone FA: Philadelphia, WB Saunders. 1982, pp 661-756
  9. Perrouin-Verbe B, Lenne-Aurier K, Robert R, Auffray-Calvier E, Richard I, Mauduyt de la Greve I, et al: Post-traumatic syringomyelia and post-traumatic spinal canal stenosis: a direct relationship: review of 75 patients with a spinal cord injury. Spinal Cord 1998; 36: 137-43 https://doi.org/10.1038/sj.sc.3100625
  10. Williams B: Post-traumatic syringomyelia, an update. Paraplegia 1990; 28: 296-313 https://doi.org/10.1038/sc.1990.39
  11. Attal N, Brasseur L, Parker F, Tadie M, Bouhassira D: Characterization of sensation disorders and neuropathic pain related to syringomyelia. A prospective study. Neurochirurgie 1999; 45(Suppl 1):84-94
  12. Todor DR, Mu HT, Milhorat TH: Pain and syringomyelia: a review. Neurosurg Focus 2000; 8: E11
  13. Rusbridge C, Jeffery ND: Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J 2008; 175: 164-72 https://doi.org/10.1016/j.tvjl.2006.12.007
  14. Goldberg ME, Domsky R, Scaringe D, Hirsh R, Dotson J, Sharaf I, et al: Multi-day low dose ketamine infusion for the treatment of complex regional pain syndrome. Pain Physician 2005; 8: 175-9
  15. Cheong YK, Lee C, Son Y, Song YK, Kim TY, Lee SW: The trial of continuous intravenous infusion of ketamine in patients with phantom limb pain: a case report. Korean J Pain 2006; 19: 233-6 https://doi.org/10.3344/kjp.2006.19.2.233
  16. Kvarnstrom A, Karlsten R, Quiding H, Gordh T: The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. Acta Anaesthesiol Scand 2004; 48: 498-506 https://doi.org/10.1111/j.1399-6576.2003.00330.x
  17. Gottrup H, Bach FW, Juhl FG, Jensen TS: Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain. Anesthesiology 2006; 104: 527-36 https://doi.org/10.1097/00000542-200603000-00021
  18. Dundee JW, Lilburn JK: Ketamine-lorazepam. Attenuation of psychic sequelae of ketamine by lorazepam. Anaesthesia 1978; 33: 312-4 https://doi.org/10.1111/j.1365-2044.1978.tb12413.x

피인용 문헌

  1. Preemptive Use of Ketamine on Post Operative Pain of Appendectomy vol.24, pp.3, 2011, https://doi.org/10.3344/kjp.2011.24.3.137