The Korean Journal of Pain

  • 제21권3호
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  • Pages.187-196
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  • 2008
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
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신경손상에 의해 유발된 과민통반응에서 말초 케모카인 CCL3의 역할

The Role of the Peripheral Chemokine, CCL3, in Hyperalgesia following Peripheral Nerve Injury in the Rat

  • 임중우 (연세대학교 의과대학 생리학교실) ;
  • 이현주 (연세대학교 의과대학 생리학교실) ;
  • 남택상 (연세대학교 의과대학 생리학교실) ;
  • 윤덕미 (연세대학교 의과대학 마취통증의학교실 및 마취통증의학연구소)
  • Leem, Joong Woo (Department of Physiology, Yonsei University Medical College) ;
  • Lee, Hyun Joo (Department of Physiology, Yonsei University Medical College) ;
  • Nam, Taick Sang (Department of Physiology, Yonsei University Medical College) ;
  • Yoon, Duck Mi (Department of Anesthesiology and Pain Medicine and Anesthesia & Pain Research Institute, Yonsei University Medical College)
  • 투고 : 2008.10.28
  • 심사 : 2008.11.25
  • 발행 : 2008.12.30
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초록

Background: Upregulation of one type of the pro-inflammatory chemokine (CCL2) and its receptor (CCR2) following peripheral nerve injury contributes to the induction of neuropathic pain. Here, we examined whether another type of chemokine (CCL3) is involved in neuropathic pain. Methods: We measured changes in mechanical and thermal sensitivity in the hind paws of naïve rats or rats with an L5 spinal nerve ligation (SNL) after intra-plantar injection of CCL3 or met-RANTES, an antagonist of the CCL3 receptor, CCR1. We also measured CCL3 levels in the sciatic nerve and the hind paw skin as well as CCR1 expression in dorsal root ganglion (DRG) cells from the lumbar spinal segments. Results: Intra-plantar injection of CCL3 into the hind paw of naive rats mimicked L5 SNL-produced hyperalgesia. Intra-plantar injection of met-RANTES into the hind paw of rats with L5 SNL attenuated hyperalgesia. L5 SNL increased CCL3 levels in the sciatic nerve and the hind paw skin on the affected side. The number of CCR1-positive DRG cells in the lumbar segments was not changed following L5 SNL. Conclusions: Partial peripheral nerve injury increases local CCL3 levels along the degenerating axons during Wallerian degeneration. This CCL3 binds to its receptor, CCR1, located on adjacent uninjured afferents, presumably nociceptors, to induce hyperalgesia in the neuropathic pain state.

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과제정보

연구 과제 주관 기관 : 연세대학교

참고문헌

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