한국어병학회지 (Journal of fish pathology)

  • 제21권2호
  • /
  • Pages.107-117
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  • 2008
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  • 1226-0819(pISSN)
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  • 2233-5412(eISSN)
한국어병학회 (The Korean Society of Fish Pathology)
권호 표지

Oxytetracycline의 약욕 및 경구투여에 따른 넙치(Paralichthys olivaceus) 체내 약물동태학적 특성

Pharmacokinetics of oxytetracycline in olive flounder (Paralichthys olivaceus) by dipping and oral administration

  • 정승희 (국립수산과학원 병리연구팀) ;
  • 최동림 (국립수산과학원 병리연구팀) ;
  • 김진우 (국립수산과학원 병리연구팀) ;
  • 조미라 (국립수산과학원 식품안전팀) ;
  • 서정수 (국립수산과학원 병리연구팀) ;
  • 지보영 (국립수산과학원 병리연구팀)
  • Jung, Sung-Hee (Pathology Team, National Fisheries Research & Development Institute) ;
  • Choi, Dong-Lim (Pathology Team, National Fisheries Research & Development Institute) ;
  • Kim, Jin-Woo (Pathology Team, National Fisheries Research & Development Institute) ;
  • Jo, Mi-Ra (Food Safety Research Team, NFRDI) ;
  • Seo, Jung-Soo (Pathology Team, National Fisheries Research & Development Institute) ;
  • Jee, Bo-Young (Pathology Team, National Fisheries Research & Development Institute)
  • 발행 : 20080800
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초록

The pharmacokinetic properties of oxytetracycline (OTC) were studied after dipping and oral administration to cultured olive flounder, Paralichthys olivaceus (600 g). Plasma concentrations of OTC were determined after oral dosage (50, 100 and 200 mg/kg body weight) and dipping (50, 100 and 200 ppm, 1 h) in olive flounder (average 600 g, 23±1℃). Plasma samples were taken at 3, 5, 10, 15, 24, 32, 48, 72, 120, 168 and 240 h post-dose. In oral dosage of 50, 100 and 200 mg/kg, the peak plasma concentrations of OTC, which attained at 3 h post-dose, were 0.34, 0.44 and 1.18 ㎍/㎖, respectively. In dipping of 50, 100 and 200 ppm, those of OTC which also observed at 5 h post-dose, were 0.43, 0.38 and 0.64 ㎍/㎖, respectively. Plasma concentrations of OTC were not measurable at 240 h post-dose in all experiments. The kinetic profile of absorption, distribution and elimination of OTC in plasma were analyzed fitting to a one-compartment model by WinNonlin program. The following parameters were calculated for a single dosage of 50, 100 and 200 mg/kg body weight, respectively: AUC (the area under the concentration-time curve)=31.40, 28.07 and 32.97 ㎍∙h/㎖; T1/2 (half-life)􀆫0.89, 1.12 and 0.43 h; Tmax (time for maximum concentration)= 5.25, 3.70 and 7.30 h, Cmax (maximum concentration)=0.25, 0.38 and 0.61 ㎕/㎖. Following dipping at 50, 100 and 200 ppm, these parameters were AUC􀆫15.51, 14.63 and 19.72 ㎍∙h/㎖; T1/2= 0.75, 0.41 and 0.74 h; Tmax=4.90, 7.08 and 4.68 h, Cmax=0.40, 0.32 and 0.46 ㎕/㎖.

키워드

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