Journal of Preventive Medicine and Public Health

  • 제41권1호
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  • Pages.39-44
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  • 2008
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  • 1975-8375(pISSN)
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  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
권호 표지

비알코올성 지방간과 대사증후군 및 혈청 카로테노이드와의 관련성

Associations of Non Alcoholic Fatty Liver with the Metabolic Syndrome and Serum Carotenoids

  • 박선균 (경북대학교 의과대학 예방의학교실) ;
  • 이현정 (경북대학교 대학원 식품영양학과) ;
  • 이덕희 (경북대학교 의과대학 예방의학교실) ;
  • 이성국 (경북대학교 의과대학 예방의학교실) ;
  • 천병렬 (경북대학교 건강증진연구소) ;
  • 김성애 (경북대학교 의과대학 예방의학교실) ;
  • 이혜성 (경북대학교 대학원 식품영양학과) ;
  • 손효경 (경북대학교 의과대학 예방의학교실) ;
  • 김성희 (대구 카톨릭대학교 가정의학과)
  • Park, Sun-Kyun (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Lee, Hyun-Jung (Department of Food Science and Nutrition Graduate School, Kyungpook National University) ;
  • Lee, Duk-Hee (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Lee, Sung-Kook (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Chun, Byung-Yeol (Health Promotion Research Center, Kyungpook National University) ;
  • Kim, Sung-Ae (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Lee, Hye-Sung (Department of Food Science and Nutrition Graduate School, Kyungpook National University) ;
  • Son, Hyo-Kyung (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Kim, Sung-Hi (Department of Family Medicine, Daegu Catholic University Hospital)
  • 발행 : 2008.01.31
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초록

Objectives : This study was conducted to investigate the associations of non alcoholic fatty liver with metabolic syndrome and the serum carotenoids. Methods : This study was conducted in a general hospital in South Korea from November, 2004 to August, 2005. The study subjects were 350 sampled persons who were aged from 40 years and older (males : 180, females : 170). They were grouped into the normal, mild and severe groups according to fat accumulation in their livers, as determined by ultrasonography. We analyzed the association between non alcoholic fatty liver and metabolic syndrome by multiple logistic regression analysis and we analyzed the association between non alcoholic fatty liver and the serum carotenoids by a general linear model(ANCOVA). Results : After adjustment for the effect of potential covariates, the prevalence of metabolic syndrome was associated with fat accumulation in the liver (p trend <0.001). If the odds ratio of normal group is 1.00, then that of the mild group is 2.80 (95% C.I=1.17-6.71) and that of the severe group is 7.29 (95% C.I=2.76-19.30). The prevalence of metabolic alterations fitting the criteria of metabolic syndrome, according to the class of fat accumulation in the liver, was significantly increased, except for criteria of high blood pressure, a large waist circumference and low HDL (high density lipoprotein) cholesterol level (p trend <0.001). The level of serum ${\beta}$-carotene was decreased according to the class of fat accumulation in the liver (p trend=0.036), but the levels of serum ${\alpha}$-carotene, lycopene, ${\beta}$-cryptoxanthin and lutein were not decreased. Conclusions : This study shows that non alcoholic fatty liver was associated with metabolic syndrome and with the serum ${\beta}$-carotene level.

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