Journal of Korean Biological Nursing Science
- 제10권1호
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- Pages.80-87
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- 2008
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- 2383-6415(pISSN)
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- 2383-6423(eISSN)
난소절제술로 유도된 흰쥐 비만에서 에스트로젠의 작용
Effect of Estrogen on Ovariectomy-Induced Obesity in Rats
- Chu, Sang-Hui (College of Nursing, Nursing Policy Research Institute, Yonsei University) ;
- Lee, Mi-Kyung (College of Sciences in Education, Yonsei University) ;
- Kowalski, Jill (College of Nursing, University of Illinois) ;
- Beck, Jenny (College of Nursing, University of Illinois) ;
- Schwertz, Dorie (College of Nursing, University of Illinois)
- 발행 : 2008.06.30
초록
Purpose: Hypoestrogenism caused by ovariectomy, disease, or menopause is associated with increased obesity in women. Altered fat distribution and weight gain are consequences of menopausal hypoestrogenism, but the mechanisms responsible are not completely known. This study examined the effect of estrogen on obesity in ovariectomized rats. Method: The groups of female rats were 4 weeks post ovariectomy (OVX) or, 4 weeks post-sham operation (SHAM), and 2 weeks post ovariectomy followed by 2 weeks replacement with estradiol benzoate (ER-