한국간담췌외과학회지 (Annals of Hepato-Biliary-Pancreatic Surgery)
- 제12권3호
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- Pages.196-202
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- 2008
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- 2508-5778(pISSN)
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- 2508-5859(eISSN)
근치적 절제술을 시행한 바터씨 팽대부암에서 Ki-67과 VEGF의 예후인자로서의 가능성
Ki-67 and VEGF as Possible Prognostic Factors in Radically-resected Ampulla of Vater Cancer
- 김국진 (연세대학교 의과대학 외과학교실) ;
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홍순원
(연세대학교 의과대학 병리학 교실) ;
- 박준성 (연세대학교 의과대학 외과학교실) ;
- 황호경 (연세대학교 의과대학 외과학교실) ;
- 김재근 (연세대학교 의과대학 외과학교실) ;
- 김경식 (연세대학교 의과대학 외과학교실) ;
- 최진섭 (연세대학교 의과대학 외과학교실) ;
- 윤동섭 (연세대학교 의과대학 외과학교실) ;
- 이우정 (연세대학교 의과대학 외과학교실) ;
- 지훈상 (연세대학교 의과대학 외과학교실)
- Kim, Kuk-Jin (Department of Surgery, Yonsei University College of Medicine) ;
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Hong, Soon-Won
(Department of Pathology, Yonsei University College of Medicine) ;
- Park, Joon-Seong (Department of Surgery, Yonsei University College of Medicine) ;
- Hwang, Ho-Kyung (Department of Surgery, Yonsei University College of Medicine) ;
- Kim, Jae-Keun (Department of Surgery, Yonsei University College of Medicine) ;
- Kim, Kyung-Sik (Department of Surgery, Yonsei University College of Medicine) ;
- Choi, Jin-Sub (Department of Surgery, Yonsei University College of Medicine) ;
- Yoon, Dong-Sup (Department of Surgery, Yonsei University College of Medicine) ;
- Lee, Woo-Jung (Department of Surgery, Yonsei University College of Medicine) ;
- Chi, Hoon-Sang (Department of Surgery, Yonsei University College of Medicine)
- 발행 : 2008.09.30
초록
Purpose: Ampulla of Vater cancer has a more favorable prognosis and survival than other malignant periampullary tumors. The pathologic staging of ampulla of Vater carcinoma is a key determinant of the patient's prognosis. However, we have often encountered patients in whom the course of their disease differed substantially from what would be predicted based on their clinical staging, which highlights the need to consider additional predictive factors. We applied an immunohistochemical technique to examine the expression of Ki-67 and VEGF in radically-resected ampulla of Vater carcinomas, and then compared the status of expression with several clinicopathologic factors. Methods: Sixty-four patients who underwent curative resection for ampulla of Vater cancer between January 1992 and December 2006 at the Yonsei University College of Medicine were reviewed. The relationships between the expression of molecular markers and clinicopathologic factors were determined. Results: There was no relationship between the clinicopathologic characteristics and the expression of molecular markers in patients with ampulla of Vater cancer. Among the clinicopathologic characteristics, lymph node metastasis was identified as an independent factor of survival after curative resection for ampulla of Vater carcinoma. Conclusion: Measurement of Ki-67 and VEGF in patients with ampulla of Vater carcinoma may have an important role in identifying the poor prognostic group.