췌관내유두상점액종과 췌장 점액성낭종의 감별을 위한 분자생물학적 지표의 탐색

Biological Markers for Making the Differential Diagnosis between Intraductal Papillary Mucinous Tumor and Mucinous Cystic Tumor of the Pancreas

  • 장진영 (서울대학교 의과대학 외과학교실) ;
  • 이승은 (서울대학교 의과대학 외과학교실) ;
  • 황대욱 (서울대학교 의과대학 외과학교실) ;
  • 김우호 (서울대학교 의과대학 병리학교실) ;
  • 안영준 (서울대학교 의과대학 외과학교실) ;
  • 윤유석 (서울대학교 의과대학 외과학교실) ;
  • 한호성 (서울대학교 의과대학 외과학교실) ;
  • 김선회 (서울대학교 의과대학 외과학교실)
  • Jang, Jin-Young (Department of Surgery, Seoul National University College of Medicine) ;
  • Lee, Seung-Eun (Department of Surgery, Seoul National University College of Medicine) ;
  • Hwang, Dae-Wook (Department of Surgery, Seoul National University College of Medicine) ;
  • Kim, Woo-Ho (Seoul National University College of Medicine) ;
  • Ahn, Young-Joon (Department of Surgery, Seoul National University College of Medicine) ;
  • Yoon, Yoo-Seok (Department of Surgery, Seoul National University College of Medicine) ;
  • Han, Ho-Seong (Department of Surgery, Seoul National University College of Medicine) ;
  • Kim, Sun-Whe (Department of Surgery, Seoul National University College of Medicine)
  • 발행 : 2008.06.30

초록

Purpose: Although intraductal papillary mucinous tumor (IPMT) and mucionus cystic tumor (MCT) share many common features, they are 2 clinically different disease entities. The aims of this study were to compare the clinicopathological characteristics of IPMT and MCT and to find molecular markers for making the differential diagnosis between IPMT and MCT Methods: Forty-one patients with IPMT and 29 MCT patients who all underwent resection between 1994 and 2003 were enrolled in this study. After one gastrointestinal pathologist reviewed the pathological slides, we compared the clinico-pathological features of the two diseases. Immunohistochemical staining with using 17 biological markers was performed to find useful molecular markers for making the differential diagnosis. Results: Besides the clinical features like gender, the tumor size and location, the patient's age and the radiological images, we found differences of the expressions of PR(p<0.001), ER(p<0.001), MUC2(p=0.038) and MUC5A(p=0.001) between IPMT and MCT. Conclusion: PR, ER, MUC2 and MUC5A can be useful in making the final differential diagnosis between IPMT and MCT. Considering the different gene expressions, further studies are needed to clarify the different pathogenesis of these two diseases entities.

키워드