대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)
- 제12권2호
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- Pages.51-59
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- 2008
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- 1226-7066(pISSN)
Buplueri Radix 의 1,2,4-benzentriol에 의해 유발된 DNA Damage에 대한 보호효과에 대한 연구
Protective Effect of Buplueri Radix (BR) Against 1,2,4-benzentriol Induced DNA Damage in Human Lymphocytes
- Lee, Young-Joon (Department of Preventive Medicine, Daegu Haany University) ;
- Kang, Su-Jin (School of Public Health, Seoul National University)
- 발행 : 2008.08.31
초록
Objectives : Buplueri Radix (BR), used medical plant in Korea traditional medicine, contains various compounds, including a series of triterpene saponins known as saikosaponins. We performed this study for the protective effect of BR against oxidative damage induced by 1,2,4-benzentriol(BT) in human lymphocytes. Methods : In order to investigate the protective effect of BR against carcinogens, genotoxicity induced by benzene metabolite, BT were performed using cytokinesis-block micronucleus(CBMN) assay and comet assay. Results : The frequency of micronucleus at 25, 50 and
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