Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Anticancer and Antioxidant Effects of Saturated Fatty Acid against Skin Cancer Cell Lines

포화지방산의 피부암 세포주에 대한 항암 및 항산화 효과

  • Han, Du-Seok (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Park, Yoon-Kyu (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Kim, Hyun-Jin (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Lee, Jae-Suk (Department of Beauty Science, Kwangju Wonmen's University) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 한두석 (원광대학교 치과대학 구강해부학교실) ;
  • 박윤규 (원광대학교 치과대학 구강해부학교실) ;
  • 김현진 (원광대학교 치과대학 구강해부학교실) ;
  • 이재숙 (광주여자대학교 미용과학과) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2008.12.31
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Abstract

The anticancer and antioxidant effect of different lengths of saturated fatty acids was tested on NIH3T3 fibroblasts and human skin melanoma cellsn in this study. The cell existence rate and antioxidizing capacity and optic reservation of cells were observed. This saturated fatty acid was concentration-dependent. IC50 Concentrations in NIH3T3 fibroblasts, human skin melanoma cells and DPPH radical scavenging activity of fatty acid was increasing the order of carbochain length ; caprylic acid < lauric acid < palmitic acid < stearic acid. The reduction in cell number and morphological change in human skin melanoma cells was increasing the order of carbochain length ; caprylic acid < lauric acid < palmitic acid < stearic acid. These results suggest that carbochain length of fatty acid can be used as structure-activity relationships for anticancer and antioxidant.

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