Lamotrigine 단독 과량복용으로 발생한 횡문근융해증

Rhabdomyolysis after Lamotrigine Poisoning: A Case report

  • 김건배 (국민건강보험공단 일산병원 응급의학과) ;
  • 구홍두 (국민건강보험공단 일산병원 응급의학과)
  • Kim, Gun-Bea (Department of Emergency Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Gu, Hong-Du (Department of Emergency Medicine, National Health Insurance Corporation Ilsan Hospital)
  • 발행 : 2008.12.31

초록

Lamotrigine is a newer anti-epileptic drug for adjunctive treatment of refractory epilepsy, partial seizures, generalized tonic-clonic seizures, and bipolar disorder. Lamotrigine overdose causes serious central nervous and cardiovascular problems, but reports are uncommon. Few lamotrigine overdoses have been described because anti-epileptic drug use is limited and usually used with combination of other anti-epileptic drugs. In addition, most patients visit emergency departments with multi-drug overdoses, so few cases of lamotrigine poisoning alone exist. We had a female patient visit our emergency department a couple of hours after a lamotrigine overdose treated with intravenous hydration and urine alkalization by NaHCO3. She recovered successfully without any evidence of renal injury. However, she developed profound rhabdomyolysis, a previously unreported complication of this medication. We suggest that serial creatine kinase levels should be measured after lamotrigine poisoning.

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