대한임상독성학회지 (Journal of The Korean Society of Clinical Toxicology)
- 제6권2호
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- Pages.142-145
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- 2008
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- 1738-1320(pISSN)
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- 2508-6332(eISSN)
Lamotrigine 단독 과량복용으로 발생한 횡문근융해증
Rhabdomyolysis after Lamotrigine Poisoning: A Case report
- Kim, Gun-Bea (Department of Emergency Medicine, National Health Insurance Corporation Ilsan Hospital) ;
- Gu, Hong-Du (Department of Emergency Medicine, National Health Insurance Corporation Ilsan Hospital)
- 발행 : 2008.12.31
초록
Lamotrigine is a newer anti-epileptic drug for adjunctive treatment of refractory epilepsy, partial seizures, generalized tonic-clonic seizures, and bipolar disorder. Lamotrigine overdose causes serious central nervous and cardiovascular problems, but reports are uncommon. Few lamotrigine overdoses have been described because anti-epileptic drug use is limited and usually used with combination of other anti-epileptic drugs. In addition, most patients visit emergency departments with multi-drug overdoses, so few cases of lamotrigine poisoning alone exist. We had a female patient visit our emergency department a couple of hours after a lamotrigine overdose treated with intravenous hydration and urine alkalization by NaHCO3. She recovered successfully without any evidence of renal injury. However, she developed profound rhabdomyolysis, a previously unreported complication of this medication. We suggest that serial creatine kinase levels should be measured after lamotrigine poisoning.