대한본초학회지 (The Korea Journal of Herbology)

  • 제23권4호
  • /
  • Pages.191-196
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  • 2008
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

자소엽(紫蘇葉) 추출물의 항응혈(抗凝血) 활성에 관한 연구(硏究)

A Study of Anticoagulation Activity from Perillae Folium Extract

  • 정경희 (중부대학교 한약자원학과) ;
  • 한신희 (중부대학교 한약자원학과) ;
  • 길기정 (중부대학교 한약자원학과)
  • Jeoung, Gyong-Hee (Dept. of Oriental Medicine Resources, Joongbu University) ;
  • Han, Sin-Hee (Dept. of Oriental Medicine Resources, Joongbu University) ;
  • Kil, Gi-Jung (Dept. of Oriental Medicine Resources, Joongbu University)
  • 발행 : 2008.12.30
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초록

Objectives: This research was investigated to find out the effect of the anticoagulant Perillae folium extract. Methods: To examine an active effect of anticoagulation in Perillae folium extract, the study measured Prothrombin time(PT) and activated partial thromboplastin time(APTT) of human plasma in vitro and measured bleeding time and arterio-venous shunt model in rats in vivo. Results: Bleeding time of Perillae folium extract in vivo had a significant increase 1.6 times and thrombus weight of Perillae folium extract had a significant reduction of thrombus weight as 68%. Perillae folium extract had an effect of anticoagulation by operating on extrinsic pathway factor II, V, VII, X and intrinsic pathway factor VIII, IX, X, VI, VII in the coagulation system. Conclusions: Considering the above mentioned results, it is judged that a Perillae folium extract has a control effect of thrombus creation.

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