대한본초학회지 (The Korea Journal of Herbology)

  • 제23권4호
  • /
  • Pages.103-112
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  • 2008
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

인동등지골피탕(忍冬藤地骨皮湯)이 Streptozotocin으로 유발된 흰쥐에서의 항당뇨 효과에 대한 연구

Anti-diabetic Effect of Indongdeungjikolpi-tang in Streptozotocin-induced Diabetic Rats

  • 배효상 (동국대학교 한방병원 사상체질과) ;
  • 박성식 (동국대학교 한방병원 사상체질과) ;
  • 정진기 (동국대학교 한방신약개발센터.한의학연구소) ;
  • 윤철호 (동국대학교 한방병원 신계내과) ;
  • 변상혁 (세명대학교 한의과대학 내과학교실) ;
  • 박용기 (동국대학교 한방신약개발센터.한의학연구소)
  • Bae, Hyo-Sang (Department of Sassang Constitunal Medicine, Dongguk University Oriental Hospital) ;
  • Park, Seong-Sik (Department of Sassang Constitunal Medicine, Dongguk University Oriental Hospital) ;
  • Jung, Jin-Ki (Oriental Medicine Drug R&D Center and Oriental Medicine Research Institute, Dongguk University) ;
  • Yoon, Cheol-Ho (Department of Internal Medicine, Dondduk University Oriental Hospital) ;
  • Byun, Sang-Hyuk (Department of Internal Medicine, College of Oriental Medicine, Semyung University) ;
  • Park, Yong-Ki (Oriental Medicine Drug R&D Center and Oriental Medicine Research Institute, Dongguk University)
  • 발행 : 2008.12.30
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초록

Objectives: Indongdeungjikolpi-tang(IJT) is used as a traditional treatment of diabetes in oriental clinincs. This study aimed to evaluate the anti-diabetic effect of Indongdeungjikolpi-tang(IJT) in streptozotocin(STZ)-induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of streptozotocin(STZ; 60 mg/kg BW) to Sprague-Dawley male rats. Experimental animals(six per group), were treated by oral administration of IJT(100 and 500 mg/kg BW) and glibendimide(3 mg/kg), a known antidiabetic drug for comparison, during 4 weeks. We measured the levels of glucose, insuline, triglyceride, creatinine and urea in sera of each group. An oral glucose tolerance test(OGTT) was also performed in all groups. Results: IJT(100 and 500 mg/kg) significantly reduced blood glucose levels and increased plasma insulin levels in STZ-induced diabetic rats. IJT also significantly reduced the plasma levels of tryglyceride, creatinine and urea in STZ-induced diabetic rats. The OGTT results showed a significant improvement in glucose tolerance in IJT-administrated rats. Conclusions: These data indicate that IJT may improve glocose homeostasis in STZ-induced diabetes, which could be associated with stimulation of insulin secretion.

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