대한본초학회지 (The Korea Journal of Herbology)
- 제23권4호
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- Pages.91-101
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- 2008
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
백렴의 알레르기 염증반응에 대한 억제효과
The Effects of Ampelopsis Radix on Allergic Inflammation in PMA-stimulated Human Mast Cells
- 김장현 (동국대학교 한의과대학 한방소아과) ;
- 천진홍 (동국대학교 한의과대학 한방소아과) ;
- 김성윤 (동국대학교 한의과대학 본초학교실) ;
- 박용기 (동국대학교 한의과대학 본초학교실)
- Kim, Jang-Hyun (Department of Pediatrics, College of Oriental Medicine, Dongguk University) ;
- Chun, Jin-Hong (Department of Pediatrics, College of Oriental Medicine, Dongguk University) ;
- Kim, Sung-Yun (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
- Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
- 발행 : 2008.12.30
초록
Objectives: In this study, we investigated the inhibitory effects of Ampelopsis Radix methanol(AR-M) extract on allergic inflammation in activated human mast cells and its potential therapeutic or toxic effects. Methods: Ampelopsis Radix(AR) was extracted with 80% methanol. HMC-1 cells, a human mast cell line, were treated with different concentrations of AR-M extract, and then stimulated with PMA plus A23187. The cell toxicity of AR-M extract was determined by MTT assay. The concentrations of