Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Prior Gastrodia elata Blume diet on Diabetic Mellitus Induced Rats at Antioxidant Effect and Pathophysiology factor

선행된 천마식이가 당뇨유발백서의 항산화효과 및 병태생리학적 인자에 미치는 영향

  • Sim, Ki-Cheol (Department of Physical Therapy, Dongshin University) ;
  • Kim, Eun-Jung (Department of Physical Therapy, Dongshin University) ;
  • Chung, Hun-Woo (Department of Oriental Medicine, Dongshin University) ;
  • Kim, Gi-Do (Department of Physical Therapy, Dongshin University) ;
  • Kim, Kyoung-Yoon (Department of Physical Therapy, Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University)
  • Published : 2008.12.25
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Abstract

The purpose of this study was investigation to examine the prevention diabetic mellitus and treatment effect on Gastrodia Elata Blume(GEB) dieted at prior and after induced diabetic application. Prior induced diabetic 3 weeks ago application GEB dieted. It is to analysis changes in body weight, blood glucose, SOD, CAT and histopathological findings. For the fingding significantly concentration diabetic rats were divided into 3 different experimental groups and each groups were induced diabetic. Experimental group Ⅰ (STZ-induced diabetic rats; n=10), experimental group Ⅱ (after induced DM and GEB dieted rats; n=10), experimental group Ⅲ (Prior GEB dieted thereafter DM induced; n=10). Prior and After GEB dieted application was that body weight, blood glucose were increase in experimental group Ⅱ, Ⅲ. Specially, group Ⅲ was significantly change than group Ⅱ at 1st weeks. and the level of CAT were significantly decrease in experimental group Ⅱ, Ⅲ than group Ⅰ. but SOD level was increase in experimental group Ⅱ, Ⅲ than group Ⅰ. In histological observation; group Ⅰ showed decrease in the intensity and incidence of vacuolations, cellular infiltration and hypertrophy of in liver and kidney. The Gomori's stain result, group Ⅰ showed disruption ${\beta}$-cell in pancrease.

Keywords

References

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