동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제22권6호
  • /
  • Pages.1532-1536
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  • 2008
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

어성초로부터 분리된 Quercetin의 Protein Tyrosine Phosphatase 1B 활성

Protein Tyrosine Phosphatase 1B Activity of Quercetin from Houttuynia Cordata

  • 최화정 (생명공학연구원 천연의학연구센터) ;
  • 배은영 (생명공학연구원 천연의학연구센터) ;
  • 노용주 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Choi, Hwa-Jung (Natural Medicines Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Bae, Eun-Young (Natural Medicines Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • No, Yong-Ju (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 발행 : 2008.12.25
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초록

Quercetin which isolated form the roots of Houttuynia cordata. was determined on the basis of IR, ID and 2D NMR specta by direct comparison with authentic compounds. Protein tyrosine phophatase 1B (PTP1B) is thought to be a negative regulator in insulin signal-transduction pathway. Insulin-resistance by the activation of PTP1B is a hallmark of both type 2 diabetes and obesity. Thus, the compound inhibiting PTP1B can improve insulin resistance and can be effective in treating type 2 diabetes and obesity. Quercetin which measured the inhibitory activity against PTP1B was 92.1% inhibition in the 30 ${\mu}g$/mL, 83.4% inhibition in the 6 ${\mu}g$/mL and 76.5% inhibition in the 3 ${\mu}g$/mL. These results suggest that quercetin retains a potential PTP1B activity.

키워드

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