동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제22권6호
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  • Pages.1509-1517
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  • 2008
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

Lonicera Flower의 항산화활성과 LDL 산화 억제효과 및 혈전용해능에 관한 연구

Screening of Anti-atherosclerotic Effect of Lonicera Flower by Antioxidative and Anti-thrombotic Mechanism

  • 주신탁 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 이민자 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 이혜숙 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 정현정 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 김혁 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 김재은 (동국대학교 한의과대학 기초의과학연구센터 & 병리학교실) ;
  • 박선동 (동국대학교 한의과대학 기초의과학연구센터 & 방제학교실) ;
  • 박원환 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실)
  • Ju, Shin-Tak (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee, Min-Ja (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee, Hye-Sook (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Jung, Hyun-Jung (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim, Hyuck (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim, Jai-Eun (Cardiovascular Medical Research Center and Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Park, Sun-Dong (Cardiovascular Medical Research Center and Department of Prescriptionology, College of Oriental Medicine, Dongguk University) ;
  • Park, Won-Hwan (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University)
  • 발행 : 2008.12.25
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초록

The flowers and buds of Lonicera Flower (LF), are used in Korean herbal medicine for latent-heat-clearing, antipyretic, detoxicant and anti-inflammatory ailments. This plant is used worldwide for the treatment of many types of inflammatory disease including respiratory infections, diabetes mellitus, rheumatoid arthritis and play an important role in immune reaction. These pharmaceutical effects of LF looks like to be related to its antioxidant capacity and phytochemicals containing in LF. In this study, the antioxidant activity of extract from LF was studied in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on $Cu^{2+}$ induced human LDL oxidation and the inhibitory effect on collagen induced platelet aggregation. The LF extracts were found to have a potent scavenging activity, as well as an inhibitory effect on LDL oxidation and on platelet aggregation. In conclusion, the LF extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drug against oxidative stress and atherosclerosis.

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