Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Antihypertensive Effect of Wild Mountain Ginseng Cultured Root Extract in Spontaneously Hypertensive Rats

Spontaneously Hypertensive Rats에 있어서 산삼배양근 추출물의 항고혈압 효과

  • Yang, Deok-Chun (Korean Ginseng Center for Most Valuable Products & Ginseng Genetic Resource Bank, Kyung Hee University) ;
  • In, Jun-Gyo (Institute of Biotechnology, Biopia Co. Ltd.) ;
  • Lee, Bum-Soo (Institute of Biotechnology, Biopia Co. Ltd.) ;
  • Han, Seung-Ho (Geumsan Ginseng & Medicinal Crop Experiment Station) ;
  • Kim, Eun-Jeong (Department of Applied Biology, Chungnam National University) ;
  • Kim, Kil-Soo (College of Veterinary Medicine, Kyungpook National University)
  • 양덕춘 (경희대학교 고려인삼명품화사업단 및 인삼유전자원소재은행) ;
  • 인준교 (바이오피아 생명공학연구소) ;
  • 이범수 (바이오피아 생명공학연구소) ;
  • 한승호 (금산인삼약초작물시험장) ;
  • 김은정 (충남대학교 농업생명과학대학) ;
  • 김길수 (경북대학교 수의과대학)
  • Published : 2008.12.25
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Abstract

The antihypertensive effects of the Wild Mountain Ginseng Cultured Root Extract (WMGCE) were investigated in spontaneously hypertensive rats (SHR). Daily oral administration of the WMGCE (100 and 200 mg/kg) exhibited a significant decrease in blood pressure in SHR rats during for 8 weeks. The systolic blood pressure was dose- and time-dependently decreased significantly from the second weeks (p < 0.05) to the end of WMGCE treatment in SHR. The WMGCE decreased the plasma levels of sodium, potassium, chlorides, urea and osmolarity in SHR rats but no statistically significant change was observed. Furthermore, no significant changes were noted on heart weight, heart rate and diameter of aorta after WMGCE treatment in SHR. Our results suggest that daily oral administration of WMGCE at the dose of 100 and 200 mg/kg for 8 weeks exhibited antihypertensive activities.

Keywords

References

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