Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Studies on the Cytoprotective and Anti-inflammatory Effects of Isolate from Galla Rhois

오배자의 생리활성 연구

  • Kim, Bo-Mi (Department of Bionanochemistry, College of Natural Sciences, Wonkwang University) ;
  • Kwon, Tea-Ho (Department of Pet Animal-Plant Scienle, Wonkwang University) ;
  • Chai, Kyu-Yun (Department of Bionanochemistry, College of Natural Sciences, Wonkwang University)
  • 김보미 (원광대학교 자연과학대학 생명나노화학과) ;
  • 권태호 (원광대학교 자연과학대학 애완 동.식물학과) ;
  • 채규윤 (원광대학교 자연과학대학 생명나노화학과)
  • Published : 2008.12.25
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Abstract

Galla Rhois is a nest of parasitic bug, has been traditionally used for the treatment of the therapy of diarrhea, peptic ulcer, hemauria, etc., that showed various anti-inflammatory activity, and other biological properties. We studied the effect of Galla Rhois ethanol extract. we investigated whether compounds isolated from the ethanol extract of Galla Rhois, could modulate iNOS and COX-2 expression in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS). We found compounds that suppressed LPS-induced iNOS and COX-2 expression. Suppression of the expression of iNOS and COX-2 was in parallel with the comparable inhibition of the production of nitric oxide (NO) and prostaglandin E2 (PGE2). Our results suggest that compounds can inhibit NO and PGE2 productions through suppression of LPS-induced iNOS and COX-2 expression. Because COX-2- or iNOS-dependent mechanisms are involved in inflammation and tumor progression, our findings provide a new uncovering mechanism responsible for anti-inflammatory and antitumor effects of Galla Rhois.

Keywords

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