Genomics & Informatics

  • 제6권4호
  • /
  • Pages.173-180
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  • 2008
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  • 1598-866X(pISSN)
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  • 2234-0742(eISSN)
한국유전체학회 (Korea Genome Organization)
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Identification and Characterization of Human Genes Targeted by Natural Selection

  • Ryu, Ha-Jung (Asan Institute for Life Sciences, University of Ulsan College of Medicine) ;
  • Kim, Young-Joo (KRIBB) ;
  • Park, Young-Kyu (KRIBB) ;
  • Kim, Jae-Jung (Asan Institute for Life Sciences, University of Ulsan College of Medicine) ;
  • Park, Mi-Young (Asan Institute for Life Sciences, University of Ulsan College of Medicine) ;
  • Seo, Eul-Ju (Genome Research Center for Birth Defects and Genetic Disorders, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yoo, Han-Wook (Genome Research Center for Birth Defects and Genetic Disorders, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, In-Sook (Genome Research Center for Birth Defects and Genetic Disorders, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Oh, Berm-Seok (Department of Biomedical Engineering, Kyung Hee University School of Medicine) ;
  • Lee, Jong-Keuk (Asan Institute for Life Sciences, University of Ulsan College of Medicine)
  • 발행 : 2008.12.31
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초록

The human genome has evolved as a consequence of evolutionary forces, such as natural selection. In this study, we investigated natural selection on the human genes by comparing the numbers of nonsynonymous (NS) and synonymous (S) mutations in individual genes. We initially collected all coding SNP data of all human genes from the public dbSNP. Among the human genes, we selected 3 different selection groups of genes: positively selected genes (NS/S${\geq}$3), negatively selected genes (NS/S${\leq}$1/3) and neutral selection genes (0.9

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참고문헌

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