References
- Takeda K, Akira S. Toll-like receptors in innate immunity. Int. Immunol. 17: 1-14 (2005)
- Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1: 135-145 (2001) https://doi.org/10.1038/35100529
- O'Neill LA. TLRs: Professor Mechnikov, sit on your hat. Trends Immunol. 25: 687-693 (2004) https://doi.org/10.1016/j.it.2004.10.005
- Vogel SN, Fitzgerald KA, Fenton MJ. TLRs: Differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 3: 466-477 (2003) https://doi.org/10.1124/mi.3.8.466
- Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282: 2085-2088 (1998) https://doi.org/10.1126/science.282.5396.2085
- Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11: 443-451 (1999) https://doi.org/10.1016/S1074-7613(00)80119-3
- Takeuchi O, Kawai T, Muhlradt PF, Morr M, Radolf JD, Zychlinsky A, Takeda K, Akira S. Discrimination of bacterial lipoproteins by toll-like receptor 6. Int. Immunol. 13: 933-940 (2001) https://doi.org/10.1093/intimm/13.7.933
- Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S. Cutting edge: Role of toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169: 10-14 (2002) https://doi.org/10.4049/jimmunol.169.1.10
- Meier A, Kirschning CJ, Nikolaus T, Wagner H, Heesemann J, Ebel F. Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol. 5: 561-570 (2003) https://doi.org/10.1046/j.1462-5822.2003.00301.x
- Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by toll-like receptor 5. Nature 410: 1099-1103 (2001) https://doi.org/10.1038/35074106
- Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303: 1522-1526 (2004) https://doi.org/10.1126/science.1094351
- Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308: 1626-1629 (2005) https://doi.org/10.1126/science.1109893
- Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3. Nature 413: 732-738 (2001) https://doi.org/10.1038/35099560
- Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526-1529 (2004) https://doi.org/10.1126/science.1093620
- Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A toll-like receptor recognizes bacterial DNA. Nature 408: 740-745 (2000) https://doi.org/10.1038/35047123
- Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198: 513-520 (2003) https://doi.org/10.1084/jem.20030162
- Rhee SH, Hwang D. Murine toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF-kappaB and expression of the inducible cyclooxygenase. J. Biol. Chem. 275: 34035-34040 (2000) https://doi.org/10.1074/jbc.M007386200
- Urizar NL, Moore DD. Gugulipid: A natural cholesterol-lowering agent. Annu. Rev. Nutr. 23: 303-313 (2003) https://doi.org/10.1146/annurev.nutr.23.011702.073102
- Sinal CJ, Gonzalez FJ. Guggulsterone: An old approach to a new problem. Trends Endocrin. Met. 13: 275-276 (2002) https://doi.org/10.1016/S1043-2760(02)00640-9
- Gujral ML, Sareen K, Tangri KK, Amma MK, Roy AK. Antiarthritic and anti-inflammatory activity of gum guggul (Balsamodendron mukul Hook). Indian J. Physiol. Pharmacol. 4: 267-273 (1960)
- Sharma JN. Comparison of the anti-inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. Arznei. -Forsch. 27: 1455-1457 (1997)
- Satyavati GV. Gum guggul (Commiphora mukul)--the success story of an ancient insight leading to a modern discovery. Indian J. Med. Res. 87: 327-335 (1988)
- Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc. Drugs Ther. 8: 659-664 (1994) https://doi.org/10.1007/BF00877420
- Wu J, Xia C, Meier J, Li S, Hu X, Lala DS. The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol. Endocrinol. 16: 1590-1597 (2002) https://doi.org/10.1210/me.16.7.1590
- Owsley E, Chiang JY. Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7 alpha-hydroxylase gene. Biochem. Bioph. Res. Co. 304: 191-195 (2003) https://doi.org/10.1016/S0006-291X(03)00551-5
- Brobst DE, Ding X, Creech KL, Goodwin B, Kelley B, Staudinger JL. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J. Pharmacol. Exp. Ther. 310: 528-535 (2004) https://doi.org/10.1124/jpet.103.064329
- Burris TP, Montrose C, Houck KA, Osborne HE, Bocchinfuso WP, Yaden BC, Cheng CC, Zink RW, Barr RJ, Hepler CD, Krishnan V, Bullock HA, Burris LL, Galvin RJ, Bramlett K, Stayrook KR. The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand. Mol. Pharmacol. 67: 948-954 (2005) https://doi.org/10.1124/mol.104.007054
- Shishodia S, Aggarwal BB. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J. Biol. Chem. 279: 47148-47158 (2004) https://doi.org/10.1074/jbc.M408093200
- Ichikawa H, Aggarwal BB. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin. Cancer Res. 12: 662-668 (2006) https://doi.org/10.1158/1078-0432.CCR-05-1749
- Cheon JH, Kim JS, Kim JM, Kim N, Jung HC, Song IS. Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis. Inflamm. Bowel Dis. 12: 1152-1161 (2006) https://doi.org/10.1097/01.mib.0000235830.94057.c6
- Hwang JH, Choi SY, Ko HC, Jang MG, Jin YJ, Kang SI, Park JG, Chung WS, Kim SJ. Anti-inflammatory effect of the hot water extract from Sasa quelpaertensis leaves. Food Sci. Biotechnol. 16: 728-733 (2007)
- Park JY, Park CM, Kim JJ, Noh KH, Cho CW, Song YS. The protective effect of chlorophyll a against oxidative stress and inflammatory processes in LPS-stimulated macrophages. Food Sci. Biotechnol. 16: 205-211 (2007)
- Youn HS, Lee JY, Saitoh SI, Miyake K, Kang KW, Choi YJ, Hwang DH. Suppression of MyD88- and TRIF-dependent signaling pathways of toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochem. Pharmacol. 72: 850-859 (2006) https://doi.org/10.1016/j.bcp.2006.06.021
- Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex. J. Immunol. 175: 3339-3346 (2005) https://doi.org/10.4049/jimmunol.175.5.3339
- Youn HS, Saitoh SI, Miyake K, Hwang DH. Inhibition of homodimerization of toll-like receptor 4 by curcumin. Biochem. Pharmacol. 72: 62-69 (2006) https://doi.org/10.1016/j.bcp.2006.03.022
- Youn HS, Lee JY, Saitoh SI, Miyake K, Hwang DH. Auranofin, as an anti-rheumatic gold compound, suppresses LPS-induced homodimerization of TLR4. Biochem. Bioph. Res. Co. 350: 866-871 (2006) https://doi.org/10.1016/j.bbrc.2006.09.097
- Murakami A, Ohigashi H. Targeting NOX, iNOS, and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals. Int. J. Cancer 121: 2357-2363 (2007) https://doi.org/10.1002/ijc.23161
- Simmons DL, Levy DB, Yannoni Y, Erikson RL. Identification of a phorbol ester-repressible v-src-inducible gene. P. Natl. Acad. Sci. USA 86: 1178-1182 (1989)
- Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2. Annu. Rev. Pharmacol. 38: 97-120 (1998) https://doi.org/10.1146/annurev.pharmtox.38.1.97