International Journal of Oral Biology

The Korean Academy of Oral Biology (대한구강생물학회)
권호 표지

Antimicrobial Activity of Continentalic Acid from Aralia cordata Against Enterococcus Strains

  • Jeong, Seung-Il (Department of Oral Microbiology, School of Dentistry and Biomaterial Implant Research Institute, Wonkwang University) ;
  • Yun, Yeon-Hee (Department of Oral Microbiology, School of Dentistry and Biomaterial Implant Research Institute, Wonkwang University) ;
  • Kim, Shin-Moo (Department of Clinical Pathology, Wonkwang Health Science College) ;
  • Yoon, Kui-Hyun (Department of Laboratory Medicine, Wonkwang Univ. Sanbon Hospital) ;
  • Kim, Kang-Ju (Department of Oral Microbiology, School of Dentistry and Biomaterial Implant Research Institute, Wonkwang University)
  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Continentalic acid (CA, (-)-pimara-8(14), 15-diene-19-oic acid) was isolated from the roots of Aralia cordata (Araliaceae) using bioassay-guided fractionation of a crude chloroform extract. The antibacterial activity of CA against Enterococcus faecalis and Enterococcus gallinarium was estimated by determining minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs). CA exhibited potent activity against standard vancomycin-resistant enterococci (VRE) and vancomycin-susceptible enterococci (VSE), with MICs and MBCs values between 4 and $8{\mu}g/mL$ and 4 and $16{\mu}g/mL$, respectively. This compound exhibited potent activity against strains of VRE, which are highly resistant to clinically useful antibiotics. These findings suggest that continentalic acid may be useful in controlling enterococcal infection.

Keywords

References

  1. American Society for Microbiology (ASM) Task force on antibiotic resistance. Report of the ASM task force on antibiotic resistance. Antimicrob Agents Chemother. 1995;39: 2-23
  2. Baek DH. Screening of antimicrobial activity among the therapeutic herbal extracts on dental pathogens. Int J Oral Biol. 2007;32:75-8
  3. Colombo AP, Haffajee AD, Dewhirst FE, Paster BJ, Smith CM, Cugini MA, Socransky SS. Clinical and microbiological features of refractory periodontitis subjects. J Clin Periodontol. 1998;25:169-80 https://doi.org/10.1111/j.1600-051X.1998.tb02424.x
  4. Dahlen G, Samuelsson W, Molander A, Reit C. Identification and antimicrobial susceptibility of enterococci isolated from the root canal. Oral Microbiol Immunol. 2000;15: 309-12 https://doi.org/10.1034/j.1399-302x.2000.150507.x
  5. Dang NH, Zhang X, Zheng M, Son KH, Chang HW, Kim HP, Bae K, Kang SS. Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb. Arch Pharm Res. 2005;28: 28-33 https://doi.org/10.1007/BF02975131
  6. Davis J. Inactivation of antibiotics and the dissemination of resistance genes. Science. 1994;264: 375-81 https://doi.org/10.1126/science.8153624
  7. Han BH, Han YN, Han KA, Park MH, Lee EO. Studies on the anti-inflammatory activity of Aralia continentalis (I). Arch Pharm Res. 1983;6: 17-23 https://doi.org/10.1007/BF02855697
  8. Hur JM, Yang CH, Han SH, Lee SH, You YO, Park JC, Kim KJ. Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureus. Fitoterapia. 2004;75:603-5 https://doi.org/10.1016/j.fitote.2004.06.005
  9. Jeong SI, Han WS, Yun YH, Kim KJ. Continentalic acid from Aralia continentalis shows activity against methicillinresistant Staphylococcus aureus. Phytother Res. 2006;20:511-4 https://doi.org/10.1002/ptr.1894
  10. Kim KJ, Kim JH. Anti-proliferative and anti-telomerase activity of Curcuma rhizome extract on oral squamous cell carcinoma and osteosarcoma cells. Int J Oral Biol. 2007;32:135-41
  11. Kim, KJ, Yu HH, Jeong SI, Cha JD, Kim SM, You YO. Inhibitory effects of Caealpinia sappan on growth and invasion of methicillin-resistant Staphylococcus aureus. J Ethnopharmacol. 2004; 91: 81-7 https://doi.org/10.1016/j.jep.2003.11.017
  12. Kim KJ, Yu HH, Cha JD, Seo SJ, Choi NY, You YO. Antibacterial activity of Curcuma longa L. against methicillin-resistant Staphylococcus aureus. Phytother Res. 2005; 19: 599-604 https://doi.org/10.1002/ptr.1660
  13. Kim JS, Kang SS. Saponins from the aerial parts of Aralia continentalis. Nat Prod Sci 1998;4: 45-50
  14. Lee IS, Jin W, Zhang X, Hung TM, Song KS, Seong YH, Bae K. Cytotoxic and COX-2 inhibitory constituents from the aerial parts of Aralia cordata. Arch Pharm Res. 2006; 29: 548-55 https://doi.org/10.1007/BF02969263
  15. Moellering RC. Emergence of enterococcus as a significant pathogen. Clin Infect Dis. 1992; 14: 1173-8 https://doi.org/10.1093/clinids/14.6.1173
  16. Okuyama E, Nishimura S, Yamazaki M. Analgesic principles from Aralia cordata Thunb. Chem Pharm Bull 1991; 39: 405-7 https://doi.org/10.1248/cpb.39.405
  17. Seong CN, Shim ES, Kim SM, Yoo JC. Prevalence and characterization of vancomycin-resistant enterococci in chicken intestines and humans of Korea. Arch Pharm Res.2004; 27: 246-53 https://doi.org/10.1007/BF02980113
  18. Sinclair S. Chinese herbs: a clinical review of Astragalus, Ligusticum, and Schizandrae. Altern Med Rev.1998; 3: 338-44
  19. Spratt BG. Resistance to antibiotics mediated by target alterations. Science. 1994;264: 388-93 https://doi.org/10.1126/science.8153626
  20. Wikler MA, Bush K, Cockerill FR, Dudley MN, Eliopoulos GM, Hardy DJ,Hecht DW, Hindler JF, Patel JB, Powell M, Turnidge JD, Weinstein MP, Zimmer BL, Ferraro MJ, Swenson JM. Performance standards for antimicrobial susceptibility testing. Eighteenth Informational Supplement. M100-S18. pp 54-56. Clinical and Laboratory Standards Institute (CLSI). Wayne, PA, USA, 2005