International Journal of Oral Biology

  • 제33권4호
  • /
  • Pages.197-203
  • /
  • 2008
  • /
  • 1226-7155(pISSN)
  • /
  • 2287-6618(eISSN)
대한구강생물학회 (The Korean Academy of Oral Biology)
권호 표지

Antimicrobial Susceptibility of Viridans Streptococci Plaque Isolates in Korea

  • Shin, Kyung-Min (Department of Oral Microbiology, College of Dentistry, Seoul National University) ;
  • Choe, Son-Jin (Department of Oral Microbiology, College of Dentistry, Seoul National University) ;
  • Lee, Si Young (Department of Oral Microbiology, College of Dentistry, Research Institute of Oral Science, Kangnung National University)
  • 발행 : 2008.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

It has been reported that the antimicrobial susceptibility patterns of viridans streptococci vary according to geographical region. Although several studies on the antibiotic resistance of viridans streptococci in foreign countries have been reported, little is known about the distribution of resistance among viridans streptococci in Korea. In this study, 88 isolates of viridans streptococci from Korean students' dental plaque were identified as 12 different species. The susceptibility of these isolates to 8 antibiotics was investigated. The in vitro antibiotic activity of penicillin G, ampicillin, vancomycin, streptomycin, gentamicin, erythromycin, amoxicillin, and tetracycline was measured by the broth microdilution method. The range of the minimum inhibitory concentrations (MIC), MIC50, MIC90, and the percentage of the susceptible isolates were determined. Streptococcus mutans and Streptococcus salivarius were susceptible to the 8 antibiotics. Isolates with resistance to vancomycin, streptomycin, and amoxicillin were not found. The overall resistance rates of the 88 isolates to penicillin G, ampicillin, gentamicin, erythromycin, and tetracycline were 12.5%, 62.5%, 62.5%, 26.1%, and 26.1%, respectively.

키워드

참고문헌

  1. Ardanuy C, Tubau F, Linares J, Dominguez MA, Pallares R, Martin R. Distribution of subclasses mefA and mefE of the mefA gene among clinical isolates of macrolide-resistant (M-phenotype) Streptococcus pneumoniae, viridans group streptococci, and Streptococcus pyogenes. Antimicrob Agents Chemother. 2005;49:827-29 https://doi.org/10.1128/AAC.49.2.827-829.2005
  2. de Azavedo JC, Trpeski L, Pong-Porter S, Matsumura S, Low DE. In vitro activities of fluoroquinolones against antibioticresistant blood culture isolates of viridans group streptococci from across Canada. Antimicrob Agents Chemother. 1999;43:2299-301
  3. Bantar C, Fernandez CL, Relloso S, Lanza A, Bianchini H, Smayevsky J. Species belonging to the 'Streptococcus milleri' group: antimicrobial susceptibility and comparative prevalence in significant clinical specimens. J Clin Microbiol. 1996;34:2020-22
  4. Doern GV, Ferraro MJ, Brueggemann AB, Ruoff KL. Emergence of high rates of antimicrobial resistance among viridans group streptococci in the United States. Antimicrob Agents Chemother. 1996;40:891-94
  5. Facklam R. What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin Microbiol Rev. 2002;15:613-30 https://doi.org/10.1128/CMR.15.4.613-630.2002
  6. Gershon AS, de Azavedo JC, McGeer A, Ostrowska KI, Church D, Hoban DJ, Harding GK, Weiss K, Abbott L, Smaill F, Gourdeau M, Murray G, Low DE. Activities of new fluoroquinolones, ketolides, and other antimicrobials against blood culture isolates of viridans group streptococci from across Canada, 2000. Antimicrob Agents Chemother. 2002;46:1553-56 https://doi.org/10.1128/AAC.46.5.1553-1556.2002
  7. Limia A, Jimenez ML, Alarcon T, Lopez-Brea M. Five-year analysis of antimicrobial susceptibility of the Streptococcus milleri group. Eur J Clin Microbiol Infect Dis. 1999;18:440-4 https://doi.org/10.1007/s100960050315
  8. National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A3. National Committee for Clinical Laboratory Standards. Villanova, Pa, 1993
  9. Prabhu RM, Piper KE, Baddour LM, Steckelberg JM, Wilson WR, Patel R. Antimicrobial susceptibility patterns among viridans group streptococcal isolates from infective endocarditis patients from 1971 to 1986 and 1994 to 2002. Antimicrob Agents Chemother. 2004;48:4463-5 https://doi.org/10.1128/AAC.48.11.4463-4465.2004
  10. Teng LJ, Hsueh PR, Chen YC, Ho SW, Luh KT. Antimicrobial susceptibility of viridans group streptococci in Taiwan with an emphasis on the high rates of resistance to penicillin and macrolides in Streptococcus oralis. J Antimicrob Chemother. 1998;41:621-27 https://doi.org/10.1093/jac/41.6.621
  11. Tracy M, Wanahita A, Shuhatovich Y, Goldsmith EA, Clarridge JE, III, Musher DM. Antibiotic susceptibilities of genetically characterized Streptococcus milleri group strains. Antimicrob Agents Chemother. 2001;45:1511-4 https://doi.org/10.1128/AAC.45.5.1511-1514.2001
  12. Yamamoto N, Kubota T, Tohyama M, Kanamori S, Shinzato T, Higa F, Tateyama M, Saito A. Trends in antimicrobial susceptibility of the Streptococcus milleri group. J Infect Chemother. 2002;8:134-7 https://doi.org/10.1007/s101560200023
  13. Yoo SY, Kim KJ, Lim SH et al. First isolation of Streptococcus downei from human dental plaques. FEMS Microbiol Lett. 2005;249:323-6 https://doi.org/10.1016/j.femsle.2005.06.020
  14. 국중기, 임상수, 유소영, 황호길. 치태에서 분리한 뮤탄스 연쇄상구균 및 Streptococcus anginosus의 수종 항생제에 대한 감수성 조사. 대한치과보존학회지. 2004;29:462-9
  15. 임석균, 김수관, 김미광, 국중기. 악골골수염에서 분리된 연쇄상구균의 수종 항생제에 대한 감수성 조사. 대한구강악안면학회지. 2004;30:211-7