Abstract
The effect on serum lipid of green aster juice blended with ginseng and carrot extracts was investigated using rats injected with $CCl_4$. The rats were classified with four groups: (i) normal control (NC), (ii) rats fed with the blended juice (BA), (iii) rats treated with $CCl_4$ after having been on a normal diet for 4 weeks ($NC-CCl_4$), and (iv) rats treated with $CCl_4$ after having been fed the blended juice for 4 weeks ($BA-CCl_4$). All groups had similar feed intake. The weight gains and feed efficiency ratio were lower in the $NC-CCl_4$ group. The liver weight per body weight was much higher in the $NC-CCl_4$ group than the NC group, but did not differ between the $BA-CCl_4$ and BA groups. Triglycerides increased only for the $NC-CCl_4$ group (88.72 mg/dL); the other groups had similar levels (56.48-65.33 mg/dL). The BA group had the lowest total cholesterol level (74.08 mg/dL) the other groups had similar levels (96.78-108.83 mg/dL). HDL-cholesterol was lower in the $NC-CCl_4$ group (40.56 mg/dL) compared with the NC group (48.95 mg/dL), but there was no difference between the BA and $BA-CCl_4$ groups. The LDL-cholesterol level was higher in the $NC-CCl_4$ group (55.20 mg/dL the highest level) than the NC group (43.33 mg/dL), and higher in the $BA-CCl_4$ group (50.10 mg/dL) than the BA group (18.09 mg/dL). The lipid peroxide content was much higher in the $NC-CCl_4$ group (22.61 nmol/g) than the NC group (12.52 nmol/g), but the $BA-CCl_4$ (17.41 nmol/g) and BA (13.99 nmol/g) groups were similar. The glutathione content was much lower in the $NC-CCl_4$ group ($2.25\;{\mu}mol/g$) than the NC and BA groups, and decreased to $2.63\;{\mu}mol/g$ for the $BA-CCl_4$ group. The glutathione content of the $BA-CCl_4$ recovered to the level of that in the NC group.
본 연구에서는 참취녹즙 : 당근즙액 : 인삼즙액의 혼합비율을 66.5 : 28.5 : 5로 혼합하여 제조한 혼합 참취녹즙이 사염화탄소 투여 흰쥐의 혈청지질에 미치는 영향을 조사하였다. 실험군은 정상식이군(NC군), 혼합 참취녹즙 식이군(BA군), 정상식이 4주 후 $CCl_4$를 투여하는 정상식이 사염화탄소 대조군($NC-CCl_4$군) 및 혼합 참취녹즙 식이 4주 후 $CCl_4$를 투여하는 혼합 참취녹즙 사염화탄소 대조군($BA-CCl_4$군)의 4군이었다. 식이섭취량은 모든 처리군 간에 차이가 없었으며, 증체량과 식이효율은 $NC-CCl_4$군만 크게 감소하였다. 체중 당 간의 중량비는 $NC-CCl_4$군은 NC군보다 크게 증가하였으나, $BA-CCl_4$군은 BA군과 유의적 차이가 없었다. 중성지질은 $NC-CCl_4$군만 유의적으로 증가하였고, $BA-CCl_4$군은 NC군이나 BA군과 차이가 없었다. 총 콜레스테롤 함량은 BA군만 낮았다. HDL-콜레스테롤 함량은 $NC-CCl_4$군은 유의적으로 감소하였으나, $BA-CCl_4$군은 NC군이나 BA군과 차이가 없었다. LDL-콜레스테롤 함량은 $NC-CCl_4$군(55.20 mg/dL)은 NC군(43.33 mg/dL)에 비해 유의적으로 증가하였으며, $BA-CCl_4$군(50.10 mg/dL)은 BA군(18.09 mg/dL)보다는 증가하였으나 $NC-CCl_4$군보다는 감소하는 경향이었다. Lipid peroxide 함량은 $NC-CCl_4$군은 NC군보다 크게 증가하였으나, $BA-CCl_4$군은 BA군과 유의적인 차이를 보이지 않았으며 $NC-CCl_4$군에 비해서는 크게 감소하였다. Glutathione 함량은 $NC-CCl_4$군이 $2.25\;{\mu}moles/g$로서 NC군과 BA군에 비해 크게 감소하였다. 그러나 $BA-CCl_4$군은 $2.63\;{\mu}moles/g$로서 BA군보다는 감소하였으나 NC군 수준으로 회복되었다.