The Transactions of The Korean Institute of Electrical Engineers (전기학회논문지)

The Korean Institute of Electrical Engineers (대한전기학회)
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The effect of RF electric fields from an atmospheric micro-plasma needle device on the death of cells

침형 상압 마이크로 플라즈마 장치에서 발생하는 전기장이 세포 사멸에 미치는 효과

  • 윤현진 (부산대 공대 전자전기통신공학부) ;
  • 손채화 (한국전기연구원 전기물리연구그룹) ;
  • 김규천 (부산대 치의학과) ;
  • 이해준 (부산대 공대 전자전기통신공학부)
  • Published : 2008.12.01
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Abstract

A non-thermal micron size plasma needle is applicable for medical treatment because it includes radicals, charged particles, ultraviolet emission, and strong electric fields. The electric fields around the plasma needle device driven by a radio frequency wave are investigated in order to calculate the power delivered to the cell. A commercial multi-physics code, CFD-ACE, was utilized for the calculation of electric fields for the optimization of the needle structure. The electric field and energy absorption profiles are presented with the variation of the device structure and the distance between the needle and tissues. The living tissues effectively absorb the radio frequency power from the plasma needle device with the covered pyrex structure.

Keywords

References

  1. G. Fridman, G. Friedman, A. G.utsol, A. B. Shekhter, V. N. Vasilets, A. Fridman, Plasma Process. Polyrn., vol. 5, pp. 503-533, January 2008 https://doi.org/10.1002/ppap.200700154
  2. J. F. Kolb, A.-A H. Mohamed, R. O. Price, R. J. Swanson, A. Bowman, R. L. Chiavarini, M. Stacey, and K. H. Schoenbach, Appl. Phys. Lett., vol. 92, pp. 241501-1 - 241501-3, June 2008 https://doi.org/10.1063/1.2940325
  3. K. H. Schoenbach, S. Xiao, R. P. Joshi, C. J. Thomas, T. Heeren, J. F. Kolb,S. and J. Beebe, Plasma Sci. IEEE Trans., vol. 36, no. 2, pp. 414-422, April 2008 https://doi.org/10.1109/TPS.2008.918786
  4. U. Pliquett, R.P. Joshi, V. Sridhara, K.H. Schoenbach, Bioelectrochem., vol. 70, pp. 275-282, 2007 https://doi.org/10.1016/j.bioelechem.2006.10.004
  5. K. H. Schoenbach, B. Hargrave, R. P. Joshi, J. F. Kolb, R. Nuccitelli, C. Osgood, A. Pakhomov, M. Stacey, R. J. Swanson, J. A. White, S. Xiao, and J. Zhang, IEEE Trans. Dielectr. Electr. Insul., vol. 14, no. 5, pp. 1088 - 1119, October 2007 https://doi.org/10.1109/TDEI.2007.4339468
  6. E.M. Hall, K.H. Schoenbach, and S.J. Beebe, Apoptpsis, vol. 12, pp. 1721-1731, May 2007 https://doi.org/10.1007/s10495-007-0083-7
  7. R. Nuccitelli, U. Pliquett, X. Chen, W. Ford, R. J. Swanson, S. J. Beebe, J. F. Kolb, and K. H. Schoenbach, Biochem. Biophys. Res. Commun., vol. 343, pp. 351-360, February 2006 https://doi.org/10.1016/j.bbrc.2006.02.181
  8. Q. Hu, S. Viswanadham, R. P. Joshi, K. H. Schoenbach, S. J. Beebe, and P. F. Blackmore, Phys. Rev. E, vol. 71, pp. 031914-1 - 031914-9, March 2005 https://doi.org/10.1103/PhysRevE.71.031914
  9. J. Deng, K.H. Schoenbach, E.S. Buescher, P.S. Hair, P.M. Fox, and S.J. Beebe, Biophys. J., vol. 84, pp. 2709-2714, 2003 https://doi.org/10.1016/S0006-3495(03)75076-0
  10. Y Sakiyama and D B Graves, J. Phys. D, vol. 39, PP. 3644-3652, August 2006 https://doi.org/10.1088/0022-3727/39/16/018
  11. Y Sakiyama and D B Graves, J. Appl. Phys., vol. 101, pp. 073306-1 - 073306-9, April 2007 https://doi.org/10.1063/1.2715745
  12. Y Sakiyama and D B Graves, IEEE Trans. Plasma Sci., vol. 35, no. 5, pp. 1279-1286, October 2007 https://doi.org/10.1109/TPS.2007.906129
  13. K. H. Becker, K. H. Schoenbach, and J, G. Eden, J. Phys. D., vol, 39, pp. R55-R70, January 2006 https://doi.org/10.1088/0022-3727/39/3/R01
  14. J. J. Shi and M. G. Kong, J. Appl. Phys., vol. 97, 023306, (2004) https://doi.org/10.1063/1.1834978
  15. H. J. Lee, H. J. Yoon, C. H. Shon and G. C. Kim, Int. Symp. Plasma Chem.(ISPC), vol. 18, p. 110, August 2006
  16. 손재화, 김규천, 이해준, "RF 플라즈마 및 전기장의 흑색종 (G361 melanoma) 세포에 대한 사멸효과", 대한전기학회 논문지, 56호, 제 11권, pp. 1972-1977, 2007. 8
  17. Y. Tanaka, S. Iizuka, Thin Solid Films, vol. 506, pp. 436-439, 2006 https://doi.org/10.1016/j.tsf.2005.08.034
  18. I. Szabo, J. Kappelmayer, S. I. Alekseev, M. C. Ziskin, Bioelectromagnetics, vol. 27, no. 3, pp. 233-244, April 2006 https://doi.org/10.1002/bem.20202
  19. M. K. Logani, I. Szabo, V. Makar, A. Bhanushali, S. Alekseev, M. C. Ziskin, Bioelectromagnetics, vol. 27, pp. 258-264, January 2006 https://doi.org/10.1002/bem.20208
  20. S. Takamatsu, O. Matsui, T. Gabata, S. Kobayashi, M. Okuda, T. Ougi, Y. Ikehata, I. Nagano and H. Nagae, Radiat. Med., vol. 26, no. 4, pp. 179-187, May 2008 https://doi.org/10.1007/s11604-007-0212-9
  21. M. M. Stanisic, B. Provo, D. Larson, L. Kloth, Adv. Skin Wound Care., vol. 18, no. 9, pp. 484-490, November 2005 https://doi.org/10.1097/00129334-200511000-00012
  22. http://www.cfdrc.com/