Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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A Comparison of Gene Expression Profiles between Primary Human AML Cells and Therapy-related AML Cells

  • Kim, Young-Hun (School of Life Science and Biotechnology, Kyungpook National University) ;
  • Kim, Hyung-Soo (School of Life Science and Biotechnology, Kyungpook National University) ;
  • Hwang, Jun-Mo (School of Life Science and Biotechnology, Kyungpook National University) ;
  • Lee, Jin-Seok (School of Life Science and Biotechnology, Kyungpook National University) ;
  • Kim, Seong-Gon (School of Life Science and Biotechnology, Kyungpook National University) ;
  • Park, So-Young (Environmental Toxico-Genomic&Proteomic Center, College of Medicine, Korea University) ;
  • Chang, Kyu-Tae (National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Kil-Soo (Department of Veterinary Medicine, Kyungpook National University) ;
  • Ryoo, Zae-Young (School of Life Science and Biotechnology, Kyungpook National University) ;
  • Lee, Sang-Gyu (School of Life Science and Biotechnology, Kyungpook National University)
  • Published : 2008.12.31
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Abstract

To identify genes whose expression correlated with biological features of therapy-related AML (t-AML), we analyzed the expression profiles of de novo AML t(9;11) and t-AML t(9;11) bone marrow samples using previously published SAGE data. Three-hundred twenty-nine transcripts that satisfied statistical (P<0.05) and magnitude-of-change ($\geq$ 4-fold) criteria were identified as differentially expressed between de novo AML t(9;11) and t-AML t(9;11) cells. Of these transcripts, 301 (91%) matched known genes or ESTs and were classified according to functional categories (http://david.abcc.ncifcrf.gov/). The majority of differentially expressed genes in t-AML t(9;11) were involved in the regulation of biological and metabolic processes. Especially prominent among these were genes related to immune and drug responses. These results establish a framework for developing new drugs for the treatment of t-AML.

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References

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