The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Experimental Study of Ginkgo-Chunghyul-dan on Anti-oxidant, Anti-platelet Aggregation, and Anti-hyperlipidemic Activity

  • Yun, Sang-Pil (Saint Paul's Oriental Medical Center, Seoul, Korea) ;
  • Bae, Hyung-Sup (Stroke and Neurological Disorders Center, Kyung-Hee East-West Neo Medical Center) ;
  • Park, Seong-Uk (Stroke and Neurological Disorders Center, Kyung-Hee East-West Neo Medical Center) ;
  • Jung, Woo-Sang (Department of Cardiovascular and Neurologic(Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Moon, Sang-Kwan (Department of Cardiovascular and Neurologic(Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Jung-Mi (Stroke and Neurological Disorders Center, Kyung-Hee East-West Neo Medical Center) ;
  • Ko, Chang-Nam (Stroke and Neurological Disorders Center, Kyung-Hee East-West Neo Medical Center) ;
  • Cho, Ki-Ho (Department of Cardiovascular and Neurologic(Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Young-Suk (Department of Cardiovascular and Neurologic(Stroke Center), College of Oriental Medicine, Kyung-Hee University)
  • Published : 2008.11.30
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Abstract

Objectives :Ginkgo-Chunghyul-dan (GCHD) is newly developed herbal medicine to prevent and treat stroke. In this study, we investigated whether the GCHD had antioxidant activity and anti-platelet aggregation effect in vitro and hypolipidemic activities in vivo. Methods :Anti-oxidant activity of GCHD was measured using the Blois method, anti-platelet effect of GCHD was assessed by the Born method, and hypolipidemic activities of GCHD were evaluated in corn oil- or Triton WR-1339-induced and cholesterol-fed rats. Results :GCHD showed anti-oxidant activity in the study inhibiting the formation of 1-diphenyl-2-picrylhydrazyl radicals and xanthine oxidase activity. GCHD had anti-platelet aggregation activity. GCHD significantly lowered total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in high cholesterol diet and Triton WR-1339 induced model TG in corn oil-induced model. GCHD had no acute toxicity at a single dosage. Conclusion : These results suggest that GCHD has the potential to treat hyperlipidemia and stroke.

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