대한한의학회지 (The Journal of Korean Medicine)
- 제29권5호
- /
- Pages.1-13
- /
- 2008
- /
- 1010-0695(pISSN)
- /
- 2288-3339(eISSN)
Effects of Sagunjatang-Ga-Nokyong on Neurologic Recovery in Rats after Spinal Cord Injury
- Kim, Hyun-Seok (Dae-jeon University, College of Oriental Rehabilitation medicine) ;
- Yoon, Il-Ji (Dae-jeon University, College of Oriental Rehabilitation medicine)
- 발행 : 2008.11.30
초록
Objective : This study is investigate the effects of Sagunjatang-Ga-Nokyong(SGJ-NY) treatment on regenerative responses of corticospinal tract(CST) axons in the injured spinal cord. Methods :Using rats, we damaged their spinal cord, and then applied SGJ-NY extract to the lesion. Then we observed GAP-43 and NGF protein, astrcyte, axonal regeneration responses and axonal elongation. Result :Determination of GAP-43 and NGF protein levels were increased. And increased proliferation of astrocyte and enhanced processes in astrocytes were observed by SGJ-NY treatment. Higher number of astrocytes within the injury cavity in SGJ-NY treated group were showed, yet CSPG proteins were a weaker staining in the cavity in SGJ-NY. CST axons extended into the cavity and to the caudal area in SGJ-NY treated group were increased. Conclusion : SGJ-NY treatment might increase neural activity in the injured spinal cord tissue, and improved axonal regeneration responses. In this process, activation of astrocytes may play a role in promoting enhanced axonal elongation. the current study show that SGJ-NY exerts positive activity on inducing nerve regeneration responses by elevating neural tissue migration activities.