Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Anti-inflammatory and analgesic activities of methanol extract of Triphala - a poly herbal formulation

  • Prabu, D. (Department of Pharmacology, C.L.Baid Metha College of Pharmacy) ;
  • Kirubanandan, S. (Centre for Biotechnology, A.C. Technology, Anna University) ;
  • Ponnudurai, K. (Department of Pharmacology, Nandini Nagar Mahavidyalaya College of Pharmacy) ;
  • Nappinnai, M. (Department of Pharmaceutics, C.L.Baid Metha College of Pharmacy) ;
  • Jinu, Alin J.S. (Department of Pharmacology, Vel's College of Pharmacy) ;
  • Renganathan, S. (Department of Chemical Engineering, A.C.Technology, Anna University)
  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Ayurveda, an ancient System of Indian Medicine, has recommended a number of drugs from indigenous plant sources for the treatment of inflammation. To evaluate the anti-inflammatory and analgesic activities of methanol extract of Triphala were investigated in Wister albino rats and mice. The methanol extract of Triphala were found to encompass substantial anti-inflammatory effect in acute and sub-acute models and analgesic effect. Animal models of carrageenan induced edema and cotton pellet induced granuloma in albino rats were used. Extract of 200 mg/kg shows significantly reduced paw edema. Analgesics activity of Triphala with 200 mg/kg shown by significant reduction of writhing. These report shows to support the use methanol extract of Triphala in relieving inflammation and pain.

Keywords

References

  1. Ahmad I, Mehmood Z, Mohammad F. (1998) Screening of some Indian medicinal plants for their antimicrobial properties. J. Ethnopharmacol. 62, 183-193 https://doi.org/10.1016/S0378-8741(98)00055-5
  2. Anonymous. (1984) Alfred Benzon Symposium Copenhagen on August 1984. In: Farnsworth NR. The role of medicinal plants in drug development, Proceedings of the Natural Products in Drug Development, Denmark
  3. Brooks PM, Day RO. (1991) Nonsteriodal antiinflammatory drugs: diffrences and similarities. N. Eng. J. Med. 3, 241-246
  4. Conner EM, Grisham MB. (1996) Inflammation, free radicals and antioxidants. Nutrition 12, 271-274 https://doi.org/10.1016/S0899-9007(96)00000-8
  5. D'Arcy PF, Haward EM, Muggleton RW, Townsend SB. (1960) The anti-inflammatory action of griseofulvin in experimental animals. J. Pharm. Pharmacol. 12, 659-665
  6. Dutta BK, Rahman I, Das TK. (1998) Antifungal activity of Indian plant extracts. Mycoses. 41, 535-536
  7. Franzotti EM, Santos CVF, Rodrigues HMSL, Mourao RHV, Andrade AR, Antoniolli AR. (2002) Antiinflammatory, analagesic and acute toxicity of Sida cardiafolia L. J. Ethnopharmacol. 72, 273-278 https://doi.org/10.1016/S0378-8741(00)00205-1
  8. Gulati R, Agarwal S, Agarwal SS. (1995) Hepatoprotective studies on Phyllanthus emblica and quercitin. Indian J. Exp. Biol. 33, 261-268
  9. Guyton KZ, Gorospe M, Holbrook NJ. (1997) Oxidative stress and the molecular biology of antioxidant defenses, pp.247-272, Cold spring Harbor laboratory press, New York
  10. Halliwell B, Gutteridge JMC. (1999) Free radicals in biology and medicine, pp.291-294, Oxford University press, Oxford
  11. Hans wohlmuth. (1997) triphala-a short review: Antioxidant properties of the Ayurvedic formulation triphala. Int. J. Pharmacog. 35, 313-317
  12. Hashimoto M, Nakajima Y. (1997) Anti-obesity agents, alphaamylase inhibitors, lipase inhibitors, foods and beverages containing plant extracts'. Jpn. Kokai Tokkyo Koho J. 9, 227-398
  13. Larsen GL, Henson PM. (1983) Mediators of inflammation. Annu. Rev. Immunol. 1, 331-335 https://doi.org/10.1146/annurev.iy.01.040183.002003
  14. Naik GH, Priyadarsini KI, Bhagirathi RG, Mishra B. (2005) In vitro antioxidant studies and free radical reactions of triphala, an ayurvedic formulation and its constituents. Phytother. Res. 19, 582-586 https://doi.org/10.1002/ptr.1515
  15. Nadkarni AK. (1976) Indian Materia Medica,Vol.1, Popular Press Ltd. Mumbai, India, p.1972
  16. Oreste Arrigoni, De Tullio MC. (2002) Ascorbic acid: much more than just an antioxidant. Biochi. et. Biophy. Acta, 1569, 1-9 https://doi.org/10.1016/S0304-4165(01)00235-5
  17. Rani G, Bala S, Grover IS. (1994) Anti-mutagenic studies of diethyl ether extract and tannin fractions of emblica myroblan (Emblica officinalis) in Ames assay. J. Plant Sci. Res. 10, 1-4
  18. Rasool M, Sabina EP. (2007) Anti-inflammatory effect of the Indian Ayurvedic herbal formulation triphala on adjuvant-induced arthritis in mice. Phytother. Res. 21, 889-894 https://doi.org/10.1002/ptr.2183
  19. Sharma RK, Dash B. (1998) Carka Samhita Vol. II. Chowkamba Sanskrit Series Office, Varanasi, India, p156
  20. Suresh K, Vasudevan DM. (1994) Augmentation of murine natural killer cell and antibody dependent cytotoxicity activities by Phyllanthus emblica, a new immunomodulator. J. Ethanopharmacol. 44, 55-60 https://doi.org/10.1016/0378-8741(94)90099-X
  21. Vane J, Booting R. (1987) Inflammation and the mechanism of action of anti-inflammatory drugs, Faseb J. 1, 85-89
  22. Valsaraj R, Pushpangadan P, Wagner Smitt U, Adsersen A, Brogger Christensen S, Sittie A, Nyman U, Nielsen C, Olsen CE. (1997) New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica. J. Nat. Prod. 60, 739-742 https://doi.org/10.1021/np970010m
  23. Trease GE, Evans WC. (1989) Text book of pharamacognosy, Oxford University press. Oxford. p.256
  24. Takagi N, Sanashiro T. (1996) Health foods containing antioxidative and anti-allergy food materials. Jpn. Kokai Tokkyo Koho J. 10, 65-70
  25. Tokura K. Kagawa S. (1995) Anticancer agents containing chebulanin from Terminalia chebula. Jpn. Kokai Tokkyo Koho J. 7, 138-165
  26. Tariq M, Hussain SJ, Asif M, Jahan M. (1977) Protective effect of fruit extracts of Emblica officinalis Gaertn. and Terminalia bellerica Roxb. in experimental myocardial necrosis in rats. Indian J. Exp. Biol. 15, 485-486
  27. Winter CA, Risley EA, Nuss GW. (1962) Carrageenan induced oedema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111, 544-547