Advances in Traditional Medicine

  • 제8권4호
  • /
  • Pages.323-328
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  • 2008
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Antibacterial, cytotoxic and neuropharmacological activities of Cerbera odollam seeds

  • Ahmed, F (Pharmacy Discipline, Khulna University) ;
  • Amin, R (Biotechnology and Genetic Engineering Discipline, Khulna University) ;
  • Shahid, IZ (Pharmacy Discipline, Khulna University) ;
  • Sobhani, MME (Biotechnology and Genetic Engineering Discipline, Khulna University)
  • 발행 : 2008.12.31
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초록

The MeOH extract of seeds of Cerbera odollam Gaertn. (Apocynaceae) was screened for its antibacterial, cytotoxic and neuropharmacological activities. The extract showed moderate anti-bacterial activity against Salmonella typhi, Streptococcus saprophyticus, and Streptococcus pyogenes. It exhibited high level cytotoxicity against brine shrimp ($LC_{50}$: $3\;{\mu}g/ml$). The extract potentiated pentobarbital induced sleeping time in mice which was further supported by the exploratory behavior test at dose of 25 mg/kg. The overall results tend to suggest the antibacterial, cytotoxic and CNS depressant activities of the extract.

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참고문헌

  1. Ahmed F, Hossain MH, Rahman AA, Shahid IZ. (2006) Antinociceptive and CNS depressant activity of the bark of Cerbera odollam Gaertn. Orient. Pharm. Exp. Med. 6, 344-348
  2. Anderson JE, Chang CJ, McLaughlin JL. (1988) Bioactive components of Allamanda schottii. J. Nat. Prod. 51, 307-308 https://doi.org/10.1021/np50056a018
  3. Capasso A, Aquino R, De Simone F, Sorrentino L. (1996) Neuropharmacological effects of extracts from Sickingia williamsii. J. Pharm. Pharmacol. 48, 592-595
  4. Chen JS, Zheng S. (1987) Poisonous plants of China, p75, Science press, Beijing
  5. Chopra RN, Nayar SL, Chopra IC. (1956). Glossary of Indian Medicinal Plants, CSIR, New Delhi
  6. Evans WC. (1989) Trease and Evan's Textbook of Pharmacognosy. 13 th edition. Cambridge University Press, London
  7. Gupta BD, Dandiya PC, Gupta M. (1971) A psychopharmacological analysis of behavior in rat. Jpn. J. Pharmacol. 21, 293-298 https://doi.org/10.1254/jjp.21.293
  8. Hien TT, Navarro-Delmasure C, Vy T. (1991) Toxicity and effects on the central nervous system of a Cerbera odollam leaf extract. J. Ethnopharmacol. 34, 201-206 https://doi.org/10.1016/0378-8741(91)90038-F
  9. Iyer GV, Narendranath M. (1975) A preliminary report on the neurological manifestation of Cerbera odollam poisoning. Indian J. Med. Res. 63, 312-314
  10. Kini PM, Pai KN. (1965) Cardiotoxic effects of Cerbera odollam. Indian Heart J. 17, 263-270
  11. Kirtikar KR, Basu BD. (1987) Indian Medicinal Plants, vol. III, $2^{nd}$ ed., pp. 1552-1553. International Book Distributors, India
  12. Laphookhieo S, Karakai CX, Chantrapromma K. (2004) Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochemistry 65, 507-510 https://doi.org/10.1016/j.phytochem.2003.10.019
  13. Meyer BN, Ferrigni NR, Putnam JB, Jacobsen LB, Nichols DE, McLaughlin JL. (1982) Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med. 45, 31-34
  14. Perez GRM, Perez LJA, Garcia DLM, Sossa MH (1998) Neuro-pharmacological activity of Solanum nigrum fruit. J. Ethnopharmacol. 62, 43-48 https://doi.org/10.1016/S0378-8741(98)00059-2
  15. Rios JL, Recio MC, Villar A. (1987) Antimicrobial activity of selected plants employed in the Spanish Mediterranean area. J. Ethnopharmacol. 21, 139-152 https://doi.org/10.1016/0378-8741(87)90124-3
  16. Roland R. (1982) Antibiotics-An introduction. Hoffman La-Roche &Co, Switzerland, p. 70-71
  17. Rollet B. (1981) Bibliography on mangroves research. 1600-1975. p. 479, UNESCO Paris, Information Retrieval Ltd., London
  18. Takagi K, Watanabe M, Saito H. (1971) Studies on the spontaneous movement of animals by the hole cross test: Effect of 2-dimethylaminoethan; its acylesters on the central nervous system. Jpn. J. Pharmacol. 21, 797-810 https://doi.org/10.1254/jjp.21.797
  19. Tedeschi LG, Tedeschi CG. (1968) Adipogenesis in the neonatally thymectomised rat. J. Pathol. Bacteriol. 96, 473-480 https://doi.org/10.1002/path.1700960226
  20. Yamauchi T, Abe F. (1987) Studies on Cerbera IV, polar cardenolide glycoside from the leaves of Cerbera odollam and Cerbera manghas. Chem. Pharm. Bull. 35, 4813-4818