Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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The Effects of Chitin Derivative and Hydroxyapatite Compound in Canine Bone

키틴 유도체와 하이드록시아페타이트 복합체가 개의 뼈에 미치는 영향

  • Lee, Hae-Beom (College of Veterinary Medicine, Second stage Brain Korea 21, Bio-Safety Research Institute, Chonbuk National University) ;
  • Shin, Seung-Ho (College of Veterinary Medicine, Second stage Brain Korea 21, Bio-Safety Research Institute, Chonbuk National University) ;
  • Kim, Min-Su (College of Veterinary Medicine, Second stage Brain Korea 21, Bio-Safety Research Institute, Chonbuk National University) ;
  • Lee, Ki-Chang (College of Veterinary Medicine, Second stage Brain Korea 21, Bio-Safety Research Institute, Chonbuk National University) ;
  • Chung, Yong-Sik (College of Engineering, Chonbuk National University) ;
  • Kim, Nam-Soo (College of Veterinary Medicine, Second stage Brain Korea 21, Bio-Safety Research Institute, Chonbuk National University)
  • 이해범 (전북대학교 수의과대학 생체안전성연구소) ;
  • 신승호 (전북대학교 수의과대학 생체안전성연구소) ;
  • 김민수 (전북대학교 수의과대학 생체안전성연구소) ;
  • 이기창 (전북대학교 수의과대학 생체안전성연구소) ;
  • 정용식 (전북대학교 공과대학) ;
  • 김남수 (전북대학교 수의과대학 생체안전성연구소)
  • Published : 2008.10.31
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Abstract

The aim of this study was to investigate bioactivities of 50% Chitin - hydroxyapatite (Chitin-H) compound and 50% Chitosan - hydroxyapatite (Chitosan-H) compound in canine bone. Ten healthy mongrel dogs (1-5 years old, 1.7 - 6.9 kg) were used in this study. These compounds had been transplanted into bilateral femur separately, and then the changes of femur were observed through the examinations of hemato-biochemical profiles, radiology, and histological profiles for 42 days. After 3 weeks, expanded radiolucent changes were observed in both areas transplanted the compounds. After 6 weeks, the area transplanted the Chitin-H compound did not observe any changes of bony tissue, while the area inserted the Chitosan-H compound was observed changes of increasing bone formation. In histological examination, infiltrations of inflammatory cells and bone absorptions were observed at both transplanted sites. However an increasing of active osteogenesis was observed at the transplanted site with Chitosan-H compound. In conclusion, Chitosan-H compound had an function of active osteogenesis as compared with Chitin-H compound. From this study, it is indicated that Chitosan-H compound would be used in dogs with severe bone defect.

Keywords

References

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