한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제25권4호
  • /
  • Pages.263-267
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  • 2008
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

Rat에서 Carboxymethylchitosan Fabric과 Low Molecular Weight Heparin의 자궁각 유착 형성 방지 상승효과

Synergistic Effects of Carboxymethylchitosan Fabric and Low Molecular Weight Heparin in Reducing Adhesion Formation in the Rat Uterine Horn Model

  • 권영삼 (경북대학교 수의과대학) ;
  • 장광호 (위스콘신-매디슨 대학교 수의과대학)
  • Kwon, Young-Sam (College of Veterinary Medicine, Kyungpook National University) ;
  • Jang, Kwang-Ho (School of Veterinary Medicine, University of Wisconsin-Madison)
  • 발행 : 2008.08.31
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초록

This study was performed to compare the efficacy of carboxymethylchitosan fabric (CMCF) with that of the combination of CMCF and low molecular weight heparin (LMWH) for the prevention of postoperative uterine adhesion in rats. Adhesions were induced by suturing both the uterine serosa and peritoneum abrased until petechial bleeding occurred. Fourteen days later, adhesions were evaluated clinically and histopathologically. The mean tensile strength was significantly decreased in the CMCF and CMCF+LMWH groups compared to that of control group, and the CMCF+LMWH group had the lowest tensile strength. The distance of adhesion site was highest in the CMCF group and slightly decreased in the CMCF+LMWH group comparing to that of control group. The inflammatory cell infiltration and neovascularization of the CMCF group were significantly lower than those of the control group. It was observed that the damage at intestinal serosa was significantly decreased in the CMCF+LMWH group comparing to that of control group. Therefore, it was concluded that CMCF and LMWH may be useful to prevent postoperative uterine adhesion in rats.

키워드

참고문헌

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