대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제28권3호
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- Pages.586-596
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- 2007
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- 1226-9174(pISSN)
3-NP에 의해 유발된 신경교세포의 산화적 손상에 대한 남성(南星)의 보호효과
The Neuroprotective Effect of Rhizoma Arisaematis on 3-NP-induced Oxidative Injury of C6 Glial Cells
- 이정섭 (원광대학교 한의과대학 심계내과학 교실) ;
- 신용진 (원광대학교 한의과대학 심계내과학 교실) ;
- 전지영 (원광대학교 한의과대학 심계내과학 교실) ;
- 설재균 (원광대학교 한의과대학 심계내과학 교실) ;
- 최철원 (성심한의원) ;
- 신선호 (원광대학교 한의과대학 심계내과학 교실) ;
- 이인 (원광대학교 한의과대학 심계내과학 교실) ;
- 남상규 (원광대학교 한의과대학 심계내과학 교실)
- Lee, Jung-Sup (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
- Shin, Yong-Jin (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
- Jeon, Ji-Young (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
- Seol, Jae-Gyun (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
- Choi, Chul-Won (SungShim Oriental Medical Clinic) ;
- Shin, Sun-Ho (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
- Lee, In (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
- Nam, Sang-Kyu (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
- 발행 : 2007.09.30
초록
Objectives : This study aimed to investigate the underlying protective mechanism of Rhizoma Arisaematis(RA) on 3-NP-induced Cytotoxicity in rat C6 glial cells. Methods : We investigated treatment ofC6 cells with 20mM 3-NP and pretreatment with RA to cause loss of cell viability. and morphological change. which was associated with elevation of ROS level. increase in Bax/Bcl2 ratio and HIF-a protein expression Results : RA inhibited 3-NP-induced cell death in C6 glial cells and inhibited the changes of the : MMPT (mitochondria membrane potential transition) and inhibited the decrease of mitochondria complex II activity and 3-NP-induced ROS generation in C6 cells. And RA decreased the activity of HIF-a and Bax. and increased the activity of