대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

3-NP에 의해 유발된 신경교세포의 산화적 손상에 대한 남성(南星)의 보호효과

The Neuroprotective Effect of Rhizoma Arisaematis on 3-NP-induced Oxidative Injury of C6 Glial Cells

  • 이정섭 (원광대학교 한의과대학 심계내과학 교실) ;
  • 신용진 (원광대학교 한의과대학 심계내과학 교실) ;
  • 전지영 (원광대학교 한의과대학 심계내과학 교실) ;
  • 설재균 (원광대학교 한의과대학 심계내과학 교실) ;
  • 최철원 (성심한의원) ;
  • 신선호 (원광대학교 한의과대학 심계내과학 교실) ;
  • 이인 (원광대학교 한의과대학 심계내과학 교실) ;
  • 남상규 (원광대학교 한의과대학 심계내과학 교실)
  • Lee, Jung-Sup (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Yong-Jin (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Jeon, Ji-Young (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Seol, Jae-Gyun (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Choi, Chul-Won (SungShim Oriental Medical Clinic) ;
  • Shin, Sun-Ho (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, In (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Nam, Sang-Kyu (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 발행 : 2007.09.30
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초록

Objectives : This study aimed to investigate the underlying protective mechanism of Rhizoma Arisaematis(RA) on 3-NP-induced Cytotoxicity in rat C6 glial cells. Methods : We investigated treatment ofC6 cells with 20mM 3-NP and pretreatment with RA to cause loss of cell viability. and morphological change. which was associated with elevation of ROS level. increase in Bax/Bcl2 ratio and HIF-a protein expression Results : RA inhibited 3-NP-induced cell death in C6 glial cells and inhibited the changes of the : MMPT (mitochondria membrane potential transition) and inhibited the decrease of mitochondria complex II activity and 3-NP-induced ROS generation in C6 cells. And RA decreased the activity of HIF-a and Bax. and increased the activity of $Bcl_2$ in C6 glial cells Conclusions : RA markedly protects C6 glial cells from 3-NP-induced oxidative injury.

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