The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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The Study of Seunggal-tang Gamibang on the Anti-allergy Effects

  • Ju, Bong-Hyun (Department of Pediatrics, College of Oriental Medicine, Dong-Eui University) ;
  • Lyu, Sun-Ae (Department of Pediatrics, College of Oriental Medicine, Dong-Eui University) ;
  • Ko, Woo-Shin (Department of Oriental Medical Ophthalmology & Otolaryngology & Dermatology, College of Oriental Medicine, Dong-Eui University) ;
  • Kim, Own-Il (Department of Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Lee, Seung-Yeon (Department of Pediatrics, College of Oriental Medicine, Dong-Eui University Clinical Research Center of Oriental Medicine, Dong-Eui University)
  • Published : 2007.08.31
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Abstract

Objectives The purpose of this study is to investigate effects of Seunggal-tang gamibang (SGT) on the PMA plus A23187-induced RBL-2H3 cells. Methods The effect of SGT on ${\beta}$ -hexosamonidase release, passive cutaneous anaphylaxis, $TNF-{\alpha}$ production and IL-4 secretion was studied. Results SGT inhibited the release of ${\beta}$ -hexosamonidase in RBL-2H3, without affecting cell viability. The passive cutaneous anaphylaxis (PCA) was inhibited by the SGT. Moreover SGT also reduced production of $TNF-{\alpha}$ and secretion of IL-4 in a dose-dependent manner. Conclusions SGT has anti-allergy effects on the RBL-2H3 cells.

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