대한한의학방제학회지 (Herbal Formula Science)
- 제15권1호
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- Pages.175-183
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- 2007
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- 1229-1218(pISSN)
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- 2288-5641(eISSN)
Anti-inflammatory Effect of Yongseollan on the LPS-activated RAW 264.7 Cells
- Jo, Mi-Jeong (College of Oriental Medicine and Development Team for The New Drug of Oriental Medicine (BK21 program), Daegu Haany University) ;
- Lee, Byung-Wook (College of Oriental Medicine, Daegu Haany University) ;
- Eom, Dong-Myung (Korea Institute of Oriental Medicine) ;
- Lee, Jong-Rok (College of Oriental Medicine, Daegu Haany University) ;
- Hwangbo, Min (College of Oriental Medicine, Daegu Haany University) ;
- Jee, Seon-Young (College of Oriental Medicine, Daegu Haany University) ;
- Kim, Sang-Chan (College of Oriental Medicine and Development Team for The New Drug of Oriental Medicine (BK21 program), Daegu Haany University)
- 발행 : 2007.06.30
초록
This study was conducted to evaluate the inhibitory effects of Yongseollan(YSL) on the production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 cells. YSL is tropical plant originating from Mexico. The biological activity of this plant is not yet evaluated systematically. The aim of the present work is to investigate a potential anti-inflammatory activity of YSL. The RAW264.7 cells were cultured in D MEM/F12 medium for 24 hrs. After serum starvation, cells were treated with YSL for 1 hr, followed by stimulating NO production with a LPS. We found that YSL has an inhibitory effect on the production of NO, iNOS expression and