대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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황기 추출물의 전투여(前投與)가 Cyclophosphamide로 유발된 호중구 감소증에 미치는 영향

Effects of Astragali Radix on Neutropenia Caused by Cyclophosphamide

  • 정승민 (경원대학교 한의과대학 내과학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실) ;
  • 고호연 (경원대학교 한의과대학 내과학교실) ;
  • 최유경 (경원대학교 한의과대학 내과학교실) ;
  • 김동우 (경원대학교 한의과대학 내과학교실) ;
  • 박종형 (경원대학교 한의과대학 내과학교실) ;
  • 전찬용 (경원대학교 한의과대학 내과학교실)
  • Jeong, Seung-Min (Department of Internal Medicine, College of Oriental Medicine, Kyung won University) ;
  • Ko, Seung-Gyu (Department of Preventive Medicine, College of Oriental medicine, Kyunghee University) ;
  • Go, Ho-Yeon (Department of Internal Medicine, College of Oriental Medicine, Kyung won University) ;
  • Choi, You-Kyung (Department of Internal Medicine, College of Oriental Medicine, Kyung won University) ;
  • Kim, Dong-Woo (Department of Internal Medicine, College of Oriental Medicine, Kyung won University) ;
  • Park, Jong-Hyung (Department of Internal Medicine, College of Oriental Medicine, Kyung won University) ;
  • Jun, Chan-Yong (Department of Internal Medicine, College of Oriental Medicine, Kyung won University)
  • 발행 : 2007.03.31
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초록

Objective : To study effects of Astragali radix on relieving neutropenia caused by cyclophosphamide. Method : We administered Astragali radixextracts for 7 days before injecting cyclophosphamide 200mg/kg to mice subcutaneously to cause neutropenia. The control group wasn't administered Astragali radix. One test group was administered Astragali radix extracts 500mg/kg and the other was administered 1000mg/kg. We observed WBC, neutrophil, lymphocyte, platelet, RBC, GOT, GPT, BUN, and creatine. Result : WBC, RBC, lymphocyte, neutrophil, and platelet improved more in mice administered Astragali radix extracts. Moreover, the 1000mg/kg group was more affected than the 500mg/kg group generally. GOT, GPT, BUN, and creatine weren't changed significantly compared with the control group. Conclusion : It is shown that Astragali radix extracts can relieve neutropenia induced by cyclophosphamide and we conclude that Astragali radix will be useful for cancer treatment.

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