대한본초학회지 (The Korea Journal of Herbology)
- 제22권2호
- /
- Pages.169-174
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- 2007
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
사역산합평위산가미방(四逆散合平胃散加味方)이 사염화탄소에 의한 간손상 모델 동물의 혈액학적 변화에 미치는 영향
Effects of Sayeoksanhap-Pyeongweisan-Gamiban(SPG) on hematological changes in animals damaged by CCl4
- 김형우 (동신대학교 한의과대학) ;
- 김성욱 (동신대학교 한의과대학) ;
- 조수진 (고려대학교 의과대학) ;
-
김부여
(동신대학교 한의과대학)
;
- 윤여충 (동신대학교 한의과대학) ;
-
조수인
(동신대학교 한의과대학)
- Kim, Hyung-Woo (College of Korean Medicine Dongshin University) ;
- Kim, Seong-Wook (College of Korean Medicine Dongshin University) ;
- Cho, Su-Jin (College of medicine Korea University) ;
-
Kim, Bu-Yeo
(College of Korean Medicine Dongshin University)
;
- Yun, Yeo-Chung (College of Korean Medicine Dongshin University) ;
-
Cho, Su-In
(College of Korean Medicine Dongshin University)
- 발행 : 2007.06.30
초록
Objectives : This study was designed to investigate protective effects of Sayeoksanhap-Pyeongweisan-Gamiban(SPG) on hematological changes in rats damaged by CCl4 Methods : We investigated the effects of SPG on hematological changes in terms of AST/ALT levels, Total cholesterol, HDL-cholesterol and triglyceride in serum and lipid peroxidation in rat liver. Results : Administration of SPG decreased AST level in serum effectively. In addition, lipid peroxidation in liver tissue, which was elevated by injection of CCl4, was decreased by administration of SPG. In contrast, ALT level, Total cholesterol, HDL-cholesterol and triglyceride in serum were not affected by administration of SPG. Conclusion : These results suggest that oral administration of SPG was useful to protect liver against CCl4 by its antioxidant action in liver tissues.