The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects on Gene Expressions in the Rat Liver of Aconitine and Aconitum Species.

부자류 및 Aconitine이 흰쥐 간 내 유전자발현에 미치는 영향

  • Lee, Jeong-Ho (Department of Natural healing, Songho University) ;
  • Han, Sang-Yong (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kim, Hyun-Ju (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Park, Hye-Jung (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kim, Yun-Kyung (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
  • 이정호 (송호대학 자연치유학과) ;
  • 한상용 (원광대학교 약학대학 한약학과) ;
  • 김현주 (원광대학교 약학대학 한약학과) ;
  • 박혜정 (원광대학교 약학대학 한약학과) ;
  • 김윤경 (원광대학교 약학대학 한약학과)
  • Published : 2007.06.30
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Abstract

Objectives : Aconitine is one of the toxic components of aconitum species. This study was carried out to evaluate gene expressions of herbal prescriptions containg aconitum species and oriental medicinal plants of aconitum species. Methods : We have measured gene expressions in the liver of aconitine, Aconitum carmichaeli DEBX., Aconitum ciliare DC. Yong Ho Whan using Sprague-Dawley rat. Gene expression in rat liver has been analyzed using codelink 10k microarray. Results : 1. Genes up-regulated over than 4 fold were 118 and down-regulated less than 4 fold were 91 in aconitine 50 ${\mu}g/kg/day$ over control. 2. Genes up-regulated of over than 4 fold were 124 and down-regulated less than 4 fold were 98 in Aconitum ciliare DC. 4g/kg/day and 169 of over than 4 fold, and 110 of less than 4 fold for Aconitum carmichaeli DEBX. 4g/kg/day, respectively. 3. Regulated genes in treatment group of Aconitum carmichaeli DEBX, Aconitum ciliare DC. and aconitine was only 2 different genes, Sulfotransferase family 4A, member 1 and Lin-7 homolog b (C. elegans). Conclusions : Gene expression profiles in liver were different among aconitine, Aconitum carmichaeli DEBX., Aconitum ciliare DC. and herbal prescription YongHo-whan. Furthermore, we can find many new genes related with effects of aconitum species.

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