The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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A Study on the Therapeutic Effect of Alzheimer's Disease of Ginseng Radix plus Crataegi Fructus.

인삼산사복합방이 Alzheimer성 치매의 치료 효과에 대한 연구

  • Han, Sin-Hee (Dept. of Oriental Health Care, Joongbu University) ;
  • Kil, Gi-Jung (Dept. of Oriental Medicine Resources, Joongbu University)
  • 한신희 (중부대학교 한방건강관리학과) ;
  • 길기정 (중부대학교 한약자원학과)
  • Published : 2007.03.30
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Abstract

Objectives : This in vitro research was conducted to investigate the effect of the Ginseng Radix plus Crataegi Fructus. on the cytokine protein release and Nitric oxide release in releted to Alzheimer's disease. Methods : Specifically, the effects of the Ginseng Radix plus Crataegi Fructus extract on $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ of BV2 microglia cell line treated with lipopolysacchride. Results: The Ginseng Radix plus Crataegi Fructus extract suppressed the production of inflammatory cytokine protein $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ and in BV2 microglia cell line treated with lipopolysacchride. Conclusion: These results suggest that the Ginseng Radix plus Crataegi Fructus extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Gin-CHF extract for Alzheimer's disease is suggested for future research.

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