Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Experimental Study on the Antidepressant Effect of Cheongsimondam-tang

청심온담탕(淸心溫膽湯)의 항우울 효과에 대한 실험적 연구

  • Park, Jin-Seuk (Dept. of Neuorpsychiatry, College of Oriental Meidicine, Dongguk University) ;
  • Lee, Ihn (Dept. of Neuorpsychiatry, College of Oriental Meidicine, Dongguk University) ;
  • Jung, Yun-Gwan (Dept. of Neuorpsychiatry, College of Oriental Meidicine, Dongguk University) ;
  • Koo, Byung-Soo (Dept. of Neuorpsychiatry, College of Oriental Meidicine, Dongguk University) ;
  • Kim, Geun-Woo (Dept. of Neuorpsychiatry, College of Oriental Meidicine, Dongguk University)
  • 박진석 (동국대학교 한의과대학 신경정신과학교실) ;
  • 이인 (동국대학교 한의과대학 신경정신과학교실) ;
  • 정윤관 (동국대학교 한의과대학 신경정신과학교실) ;
  • 구병수 (동국대학교 한의과대학 신경정신과학교실) ;
  • 김근우 (동국대학교 한의과대학 신경정신과학교실)
  • Published : 2007.03.30
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Abstract

Objective : The purpose of this study was to investigate the protective effects of Cheongsimondam-tang(COT) on the animal model of depression induced immobilization stress. Method 1) Male rats were used for this experiment. The subject were divided into 4 groups(1. normal 2. saline solution administered during immobilization stress treatment 3. COT of 100mg/kg administered 4. COT of 400mg/kg administered). 2) Immobilization stress was treated for 1 hours on day. During 2 days of immobilization stress treatment, they were executed forced swimming test, passive avoidance test, elevated plus maze test. Corticosterone in blood were measured Results 1) In EPM test, stress group showed significantly increased anxiety, COT groups showed significantly decreased anxiety. 2) In forced swimming test, COT groups did not show significantly decreased immobilization. 3) In passive avoidance test, stress group showed significantly decreased learning execution, COT groups showed significantly increased learning execution. 4) Stress group showed significantly increase in serum level of corticosterone, COT of 400mg/kg group showed significantly decreased serum level of corticosterone. Conclusion : These results suggest that Cheongsimondam-tang(COT) is effective in the treatment of depression.

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