Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Pharmacological Screening of Crude Extracts from Medicinal Plants (II)

  • Yook, Chan-Nam (Department of Food Nutrition, Wonkwang Health Science College) ;
  • Lee, Jae-Sug (Department of Hair Design, Cheongyang College) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • Published : 2007.08.25
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of crude extracts from medicinal plants on biological activity were investigated. The crude ethanol extract of H. paucistipula inhibited the growth of the Gram positive bacterium Bacillus subtilis ATCC 19659, (2 mm inhibition zone at 150 ${\mu}g$/disc) and the dermatophyte Trichophyton mentagrophytes ATCC 28185, (7 mm inhibition zone at 150 ${\mu}g$/disc), and toxic to P388 murine leukaemia cells ($IC_{50}\;2.48\;{\mu}g/ml$ at 75 ${\mu}g$/disk). This crude ethanol extract of H. paucistipula is the strongest antimicrobial and cytotoxic activities against P388 murine leukaemia cells (ATCC CCL 46 P388D1).

Keywords

References

  1. Allison, K.W. The Liverworts of New Zealand, University of Otago Press, Dunedin, 1975
  2. Connor, H.E. and Edger, E. Name changes in the indigenous New Zealand flora. 1960 - 1986 and Nomina Nova IV, 1983 -1986, New Zealand J. Bot. 25: 2255-2258, 1987
  3. Allan, H.H. Flora of New Zealand. Indigenous Tracheopphyta, Psilopsida, Lycopsida, Filicopsida, Gymnospermae, Dicotyledones, DSIR: Wellington. Vol. 1, 1960
  4. Riley, M. Maori Healing and Herbal. Paraparaumu, New Zealand: Viking Sevenseas N.Z. Ltd. 1994
  5. Asakawa, Y. In progress in the Chemistry of Organic Natural Products, Herz, W., Kirby, G.W., Moore, R.E., Steglich, W., Tamm, C., Eds. Springer Vienma, Vol. 65, 1995
  6. Zinsmeister, H.D., Becker, H. and Eicher, T. Angew. Chem. Int. Ed. Engl. 30: 130-147, 1991 https://doi.org/10.1002/anie.199101301
  7. Pharmacopeia of People Republic of China (in Chinese), 1: 81, 1985
  8. Chen, Z.L. The acetylenes from Atractylodes macrocephala. Planta Med. 493-494, 1987
  9. Tong, W. and Eisenbrand, G. Chinese Drugs of Plant Origin, Springer, Berlin, pp 191-197, 1992
  10. New Zealand Plant Names Database. http://nzflora. landcareresearch.co.nz/ Landcare Research, New Zealand: 2000, accessed 14 August 2003
  11. Asakawa, Y. In progress in the Chemistry of Organic Natural Products; Herz, W., Kirby, G.W., Moore, R.E., Steglich, W., Tamm, C., Eds. Springer Vienma, Vol. 65: 1-525, 1995
  12. Perry, N.B. Foster, L.M.J. Nat. Prod. 58: 1131-1135, 1995 https://doi.org/10.1021/np50121a027
  13. Toyota, M., Asakawa, Y. Phytochemistry 32: 137-140, 1993
  14. Benesova, V., Samek, Z., Herout, V., Sorm, F. Collect. Czech. Chem. Commun. 34: 1807-1809, 1969 https://doi.org/10.1135/cccc19691807
  15. Benesova, V., Herout, V., Sorm, F. Collect. Czech. Chem. Commun. 34: 1810-1814, 1969 https://doi.org/10.1135/cccc19691810
  16. Asakawa, Y., Toyota, M., Matsuda, R., Takikawa, K., Takemoto, T. Phytochemistry 22: 1413-1415, 1983 https://doi.org/10.1016/S0031-9422(00)84025-X
  17. Asakawa, Y., Toyota, M., Taira, Z., Takemoto, T., Kido, M. J. Org. Chem. 48: 2164-2167, 1983 https://doi.org/10.1021/jo00161a009
  18. Dienes, Z., Nogradi, M., Vermes, B., Kajtar-Peredy, M. Liebigs Ann. Chem. 1141-1143, 1989
  19. Kurata, K., Amiya, T. Bull. Chem. Soc. Jpn 53: 2020-2022, 1980 https://doi.org/10.1246/bcsj.53.2020
  20. Lorimer, S.D., Barns, G., Evans, A.C., Foster, L.M., May, B.C.H., Perry, N.B., Tangney, R.S. Phytomedicine 2: 327-333, 1996
  21. Schroeder, A.C., Hughes, R.G. Jr. and Bloch, A. Synthesis and biological effects of acyclic pyrimidine nucleoside analogues. J. Med. Chem. 24: 1078-1083, 1981 https://doi.org/10.1021/jm00141a012