Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Biochemical Makers of Bone Metabolism by Administration of Radix Concentration in Ovariectomized Rats

골다공증 쥐에서 우슬의 농도별 투여에 따른 골대사의 생화학적 마커에 미치는 영향

  • Kim, Eun-Jung (Department of Physical Therapy, Dongshin University) ;
  • Kim, Young-Eok (Department of Physical Therapy, Dongshin University) ;
  • Jang, Mee-Kyung (Department of Physical Therapy, Dongshin University) ;
  • Kim, Young-Il (Department of Pharmaceutical Engineering, Konyang University) ;
  • Kim, Hyung-Woo (College of Oriental Medicine, Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University)
  • Published : 2007.08.25
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Abstract

Osteoporosis is the most prevalent metabolic bone disease and is characterized by diminished bone strength predisposing to an increased risk of fracture. We investigated the effects of the extract from Acyranthes Radix on the progress of bone loss in ovariectomized rats for 6 weeks. Female Sprague-Dawley 40 rats of 3-4 weeks, weight 200 ${\pm}$ 10g were divided into two groups including the sham operation group(8 rats) and ovariectomy group(32 rats). The dose-dependent effect of Acyranthes Radix extract on bone mineral density and biochemical testing was assessed in ovariectomized rat. Body weights were increased in all groups was higher in experimental group than sham operation group. The level of bone mineral density, GPT, and serum P concentration, ALP were increased experimental group, but a little increase in sham operation group at same period. This longitudinal study result made conclusion that Acyranthes Radix extract treatment appeared to improve the osteoporosis delaying the progression to the osteoporotic process in rats.

Keywords

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